Molecular Weight: 538.97 g/mol
Chemical Structure
Check the
JNJ-63576253 (TRC-253)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(185.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
| CAS Number | 2110428-64-1 | |
|---|---|---|
| Molecular Formula |
C23H22ClF3N6O2S |
|
| Molecular Weight (MW) | 538.97 | |
| SMILES | Cl.FC(F)(F)C1=CC(=CN=C1C#N)N2C(=O)C3(CCC3)N(C2=S)C4=CN=C(OC5CCNCC5)C=C4 |
- JNJ-63576253 (TRC-253) Clinical Trials
- JNJ-63576253 (TRC-253) Solubility in DMSO
- JNJ-63576253 (TRC-253) Stock Solution
- JNJ-63576253 (TRC-253) Storage
- JNJ-63576253 (TRC-253) Stability
- JNJ-63576253 (TRC-253) SMILES
- JNJ-63576253 (TRC-253) CAS Number
- JNJ-63576253 (TRC-253) Chemical Structure (2D and 3D)
- JNJ-63576253 (TRC-253) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.