CAS No. 1346528-50-4
Batch:
Purity:99.99
Chemical Structure
Check the
JNJ-42165279
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(4-chloro-3-pyridinyl)-4-[(2,2-difluoro-1,3-benzodioxol-5-yl)methyl]piperazine-1-carboxamide | |
|---|---|---|
| CAS Number | 1346528-50-4 | |
| Molecular Formula |
C18H17ClF2N4O3 |
|
| Molecular Weight (MW) | 410.80 | |
| SMILES | C1CN(CCN1CC2=CC3=C(C=C2)OC(O3)(F)F)C(=O)NC4=C(C=CN=C4)Cl | |
| InChIKey | YWGYNGCRVZLMCS-UHFFFAOYSA-N |
JNJ-42165279 is a potent inhibitor of fatty acid amide hydrolase (FAAH), targeting both human and rat FAAH enzymes. By blocking FAAH-mediated degradation of endocannabinoids such as anandamide, it elevates endogenously active fatty acid amides in tissues. This modulation of endocannabinoid signaling regulates central and peripheral physiological pathways without directly activating cannabinoid receptors.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.