CAS No. 1998725-11-3
Batch:
Purity:99.85
Chemical Structure
Check the
JHU-083
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate | |
|---|---|---|
| CAS Number | 1998725-11-3 | |
| Molecular Formula |
C14H24N4O4 |
|
| Molecular Weight (MW) | 312.36 | |
| SMILES | CCOC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC(C)C)N | |
| InChIKey | YZRCHOFKIPHQBW-RYUDHWBXSA-N |
JHU-083 is a novel prodrug of 6-diazo-5-oxo-L-norleucine (DON) that acts as a glutamine antagonist and selectively blocks glutaminase activity. By inhibiting glutamine metabolism, JHU-083 disrupts nutrient flux, suppresses tumor cell proliferation, and reprograms effector T cell metabolism to enhance antitumor immune responses. Additionally, JHU-083 modulates neuroinflammatory signaling in brain CD11b+ cells to alleviate stress-induced behavioral deficits. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(198.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | 8 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.