CAS No. 3621-38-3
Batch:
Purity:99.37
Chemical Structure
Check the
Jatrorrhizine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol | |
|---|---|---|
| CAS Number | 3621-38-3 | |
| Molecular Formula |
C20H20NO4 |
|
| Molecular Weight (MW) | 338.38 | |
| SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC | |
| InChIKey | MXTLAHSTUOXGQF-UHFFFAOYSA-O |
Biological Activity
Jatrorrhizine is a natural protoberberine alkaloid that acts as an inhibitor of acetylcholinesterase (AChE,, displaying over 115-fold selectivity for AChE over butyrylcholinesterase (BuChE). By inhibiting AChE, it prevents neurotransmitter degradation to modulate downstream cholinergic signaling pathways. Additionally, jatrorrhizine exhibits broad biological activities including hypoglycemic, antimicrobial, and antioxidant effects.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Jump to
Note: Technical data last updated: Sep 1, 2026.