CAS No. 18085-97-7
Batch:
Purity:98.35
Chemical Structure
Check the
Jaceosidin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 18085-97-7 | |
|---|---|---|
| Molecular Formula |
C17H14O7 |
|
| Molecular Weight (MW) | 330.29 | |
| SMILES | COC1=C(C=CC(=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)OC)O)O |
Biological Activity
Jaceosidin is a natural flavonoid isolated from Artemisia species that acts as an anti-tumor and anti-inflammatory agent. It inhibits cyclooxygenase-2 (COX-2) expression and suppresses NF-κB signaling pathway activation. Furthermore, jaceosidin downregulates anti-apoptotic proteins including Mcl-1 and c-FLIP while stimulating pro-apoptotic Bax activation, thereby inducing apoptosis and suppressing cancer cell proliferation across diverse tumor cell lines. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.