CAS No. 1185329-96-7
| IUPAC Name | N-[1-[2-[methyl-[2-(4-methylphenoxy)ethyl]amino]-2-oxoethyl]pyrazol-4-yl]-3-phenoxypropanamide | |
|---|---|---|
| CAS Number | 1185329-96-7 | |
| Molecular Formula |
C24H28N4O4 |
|
| Molecular Weight (MW) | 436.5 | |
| SMILES | CN(CCOC1=CC=C(C)C=C1)C(=O)C[N]2C=C(NC(=O)CCOC3=CC=CC=C3)C=N2 | |
| InChIKey | ZVSKMVAWWBSNOY-UHFFFAOYSA-N |
IXA4 is a selective activator of the inositol-requiring enzyme 1 (IRE1)/XBP1s signaling axis. By selectively stimulating IRE1 to drive XBP1s transcription without globally triggering the broader unfolded protein response (UPR) or off-target stress pathways, IXA4 reduces the secretion of amyloid precursor protein (APP). This selective pathway engagement mitigates APP-associated mitochondrial dysfunction and preserves cellular homeostasis under endoplasmic reticulum stress conditions. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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