CAS No. 200626-61-5
Batch:
Purity:99.08
Chemical Structure
Check the
ITSA-1 (ITSA1)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | benzotriazol-1-yl-(2,4-dichlorophenyl)methanone | |
|---|---|---|
| CAS Number | 200626-61-5 | |
| Molecular Formula |
C13H7Cl2N3O |
|
| Molecular Weight (MW) | 292.12 | |
| SMILES | C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl | |
| InChIKey | UVNLAUGZMOPBPR-UHFFFAOYSA-N |
ITSA-1 is a small-molecule suppressor that selectively counteracts trichostatin A (TSA)-induced histone hyperacetylation and histone deacetylase (HDAC) inhibition. By suppressing TSA-mediated signaling without affecting HDAC inhibition induced by other HDAC inhibitors, ITSA-1 modulates chromatin remodeling, histone acetylation dynamics, and downstream gene transcription. Consequently, ITSA-1 rescues cells from TSA-induced growth arrest and suppresses TSA-dependent cellular phenotypes. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.