CAS No. 448906-42-1
Batch:
Purity:99.64
Chemical Structure
Check the
ITE
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate | |
|---|---|---|
| CAS Number | 448906-42-1 | |
| Molecular Formula |
C14H10N2O3S |
|
| Molecular Weight (MW) | 286.31 | |
| SMILES | COC(=O)C1=CSC(=N1)C(=O)C2=C[NH]C3=CC=CC=C23 | |
| InChIKey | KDDXOGDIPZSCTM-UHFFFAOYSA-N |
ITE is a potent endogenous agonist of the aryl hydrocarbon receptor (AHR) with a Ki of 3 nM. Upon ligand binding, AHR translocates to the nucleus to modulate gene expression through dioxin response elements, driving transcriptomic programs that govern cellular differentiation and immune function. Downstream activation of the AHR pathway by ITE suppresses inflammatory autoimmune responses and inhibits tumor cell proliferation. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.