CAS No. 1334298-90-6

Batch: Purity:99.98
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Itacitinib (INCB39110) Chemical Structure
Chemical Structure
Check the Itacitinib (INCB39110) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[1-[1-[3-fluoro-2-(trifluoromethyl)pyridine-4-carbonyl]piperidin-4-yl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
CAS Number 1334298-90-6
Molecular Formula

C26H23F4N9O
Molecular Weight (MW) 553.51
SMILES C1CN(CCC1N2CC(C2)(CC#N)N3C=C(C=N3)C4=C5C=CNC5=NC=N4)C(=O)C6=C(C(=NC=C6)C(F)(F)F)F
InChIKey KTBSXLIQKWEBRB-UHFFFAOYSA-N

Ordering Information

Biological Activity

Itacitinib (INCB39110) is an orally bioavailable small-molecule inhibitor targeting Janus kinase 1 (JAK1) with potential antineoplastic activity. By selectively inhibiting JAK1 activity, itacitinib disrupts downstream STAT protein phosphorylation and blocks signal transduction across the canonical JAK/STAT pathway. This inhibition attenuates pro-inflammatory cytokine signaling, decreases cellular proliferation, and induces targeted apoptosis in neoplastic cell populations.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.