Molecular Weight: 451.34 g/mol

ISRIB (trans-isomer) Chemical Structure
Chemical Structure
Check the ISRIB (trans-isomer) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 10 mg/mL (22.15 mM) ; Warmed with 60°C water bath ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Chemical Information

IUPAC Name 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
CAS Number 1597403-47-8
Molecular Formula
C22H24Cl2N2O4
 
 
Molecular Weight (MW) 451.34
SMILES C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
InChIKey HJGMCDHQPXTGAV-UHFFFAOYSA-N

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Note: Technical data last updated: Sep 1, 2026.