CAS No. 1597403-47-8
Batch:
Purity:99.87
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Chemical Structure
Check the
ISRIB (trans-isomer)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide | |
|---|---|---|
| CAS Number | 1597403-47-8 | |
| Molecular Formula |
C22H24Cl2N2O4
|
|
| Molecular Weight (MW) | 451.34 | |
| SMILES | C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl | |
| InChIKey | HJGMCDHQPXTGAV-UHFFFAOYSA-N |
Biological Activity
ISRIB (trans-isomer) is a potent PERK signaling inhibitor with an IC50 of 5 nM. By blocking integrated stress response activation, it reverses eIF2α phosphorylation-mediated translational attenuation and restores protein synthesis. Furthermore, ISRIB exerts its biological effects without causing global alterations in translation, transcription, or mRNA stability in non-stressed cells, thereby selectively regulating cellular stress responses. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(22.15 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.