CAS No. 470-17-7

Batch: Purity:99.99
Check CoA
Isoalantolactone Chemical Structure
Chemical Structure
Check the Isoalantolactone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 470-17-7
Molecular Formula

C15H20O2
Molecular Weight (MW) 232.32
SMILES CC12CCCC(=C)C1CC3C(C2)OC(=O)C3=C

Biological Activity

Isoalantolactone is a natural sesquiterpene lactone compound and apoptosis inducer with broad antiproliferative activity. It promotes intracellular reactive oxygen species generation, causing mitochondrial membrane depolarization and activation of caspases. This disrupts key oncogenic signaling cascades, including the STAT3 pathway, leading to inhibition of cell proliferation and induction of apoptotic cell death across multiple cancer lines.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 46 mg/mL (198.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.