CAS No. 91-56-5
Batch:
Purity:99.85
Chemical Structure
Check the
Isatin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1H-indole-2,3-dione | |
|---|---|---|
| CAS Number | 91-56-5 | |
| Molecular Formula |
C8H5NO2 |
|
| Molecular Weight (MW) | 147.13 | |
| SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2 | |
| InChIKey | JXDYKVIHCLTXOP-UHFFFAOYSA-N |
Isatin (2,3-indolinedione) is an endogenous monoamine oxidase (MAO) inhibitor with an IC50 of 15 μM that exhibits higher potency against MAO-B than MAO-A. By inhibiting MAO activity, isatin modulates monoaminergic neurotransmission and regulates signaling pathways involved in stress and anxiety responses. It elevates central monoamine levels, leading to downstream neuroprotective and behavioral phenotypes in preclinical models.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(197.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.