CAS No. 2088852-47-3

Batch: Purity:99.48
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Uzansertib (INCB053914) Chemical Structure
Chemical Structure
Check the Uzansertib (INCB053914) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl]-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide
CAS Number 2088852-47-3
Molecular Formula

C26H26F3N5O3.H3O4P
Molecular Weight (MW) 611.51
SMILES CC1CN(CC(C1O)N)C2=C3CCC(C3=NC=C2NC(=O)C4=NC(=C(C=C4)F)C5=C(C=CC=C5F)F)O.OP(=O)(O)O
InChIKey PTORCEYGCGXHDH-OVMXCRKPSA-N

Ordering Information

Biological Activity

Uzansertib (INCB053914) is an ATP-competitive, pan-PIM kinase inhibitor targeting PIM1 (IC50 0.24 nM), PIM2 (IC50 30 nM), and PIM3 (IC50 0.12 nM). By inhibiting PIM family kinase signaling, it prevents the phosphorylation of downstream substrates such as BAD and 4E-BP1, thereby suppressing protein translation, impairing cell cycle progression, and inducing apoptosis in hematologic malignancy models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (81.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.