GDC-0077 (Inavolisib) is a potent, selective, ATP-competitive PI3Kα inhibitor. It blocks PI3K/AKT/mTOR signaling by promoting mutated p110α degradation, effectively inhibiting proliferation and inducing apoptosis in PIK3CA-mutated cancer cells.
GDC-0077 (Inavolisib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for GDC-0077 (Inavolisib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.