CAS No. 2060571-02-8

Batch: Purity:99.84
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GDC-0077 (Inavolisib) Chemical Structure
Chemical Structure
Check the GDC-0077 (Inavolisib) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide
CAS Number 2060571-02-8
Molecular Formula

C18H19F2N5O4
Molecular Weight (MW) 407.37
SMILES CC(C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4C(COC4=O)C(F)F
InChIKey SGEUNORSOZVTOL-CABZTGNLSA-N

Ordering Information

Biological Activity

GDC-0077 (Inavolisib) is a potent and selective inhibitor of PI3Kα. It competes with ATP for binding to PI3Kα, thereby inhibiting the phosphorylation of PIP2 to PIP3. Blockade of this enzymatic activity suppresses downstream AKT/mTOR signaling, leading to reduced cellular proliferation and the induction of apoptosis in PI3Kα-dependent cancer cells.[1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (198.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.