Imidazole Ketone Erastin (IKE) is a potent xCT transporter inhibitor. It affects glutathione metabolism and ferroptosis signaling by depleting GSH and elevating lipid peroxidation, effectively promoting ferroptotic cell death in cancer cells.
Imidazole Ketone Erastin (IKE) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Imidazole Ketone Erastin (IKE) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.