CAS No. 1801530-11-9
| IUPAC Name | 2-[[4-[2-(4-chlorophenoxy)acetyl]piperazin-1-yl]methyl]-3-[5-(2-imidazol-1-ylacetyl)-2-propan-2-yloxyphenyl]quinazolin-4-one | |
|---|---|---|
| CAS Number | 1801530-11-9 | |
| Molecular Formula |
C35H35ClN6O5 |
|
| Molecular Weight (MW) | 655.14 | |
| SMILES | CC(C)OC1=C(C=C(C=C1)C(=O)CN2C=CN=C2)N3C(=NC4=CC=CC=C4C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(C=C6)Cl | |
| InChIKey | PSPXJPWGVFNGQI-UHFFFAOYSA-N |
Imidazole Ketone Erastin (IKE) is a potent, selective, and metabolically stable inhibitor of system xc- and an inducer of ferroptosis. By inhibiting the cystine/glutamate antiporter system xc-, IKE depletes intracellular glutathione levels, leading to the accumulation of toxic lipid reactive oxygen species. This loss of antioxidant defense promotes iron-dependent lipid peroxidation, resulting in robust non-apoptotic ferroptotic cell death and suppression of tumor growth in cancer models.
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(152.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(152.63 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(152.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 33 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(152.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(152.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Imidazole Ketone Erastin (IKE) Mechanism of Action: SLC7A11 Inhibition in Tumor Cell Research
- Imidazole Ketone Erastin (IKE) Clinical Trials
- Imidazole Ketone Erastin (IKE) Working Concentration | Cell Culture | Treatment
- Imidazole Ketone Erastin (IKE) Solubility in DMSO
- Imidazole Ketone Erastin (IKE) Stock Solution
- Imidazole Ketone Erastin (IKE) Storage
- Imidazole Ketone Erastin (IKE) Stability
- Imidazole Ketone Erastin (IKE) Combination Database
- Imidazole Ketone Erastin (IKE) Molecular Weight
- Imidazole Ketone Erastin (IKE) SMILES
- Imidazole Ketone Erastin (IKE) Chemical Structure (2D and 3D)
- Imidazole Ketone Erastin (IKE) IC50 for Cell-based and Cell-free Assays
- Imidazole Ketone Erastin (IKE) MedChemExpress (HY-114481)? Try a better option.
- Imidazole Ketone Erastin (IKE) Cayman (27088)? Try a better option.
- Imidazole Ketone Erastin (IKE) Sigma (SML4326)? Try a better option.
- Imidazole Ketone Erastin (IKE) Abmole (M10244)? Try a better option.
- Imidazole Ketone Erastin (IKE) SDS｜MSDS