CAS No. 775351-61-6

Batch: Purity:99.99
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Imeglimin (EMD 387008) Hydrochloride Chemical Structure
Chemical Structure
Check the Imeglimin (EMD 387008) Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4R)-6-N,6-N,4-trimethyl-1,4-dihydro-1,3,5-triazine-2,6-diamine;hydrochloride
CAS Number 775351-61-6
Molecular Formula

C6H13N5.ClH
Molecular Weight (MW) 191.66
SMILES Cl.CC1N=C(N)NC(=N1)N(C)C
InChIKey UXHLCYMTNMEXKZ-PGMHMLKASA-N

Ordering Information

Biological Activity

Imeglimin Hydrochloride is a novel oral glucose-lowering compound that modulates mitochondrial bioenergetics. It preserves mitochondrial function by suppressing oxidative stress and maintaining respiratory chain integrity. Through these cellular mechanisms, Imeglimin normalizes glucose tolerance, restores insulin sensitivity, and promotes hepatic lipid oxidation, thereby improving glucose homeostasis and metabolic parameters in high-fat high-sucrose diet-fed mouse models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 38 mg/mL (198.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 38 mg/mL
Ethanol 38 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.