Home Biosimilar Antibodies Immunology & Inflammation CD markers Imaprelimab (Anti-MUC18 / MCAM / CD146)
For research use only. Not for use in humans.

Imaprelimab (Anti-MUC18 / MCAM / CD146)

Synonyms: PRX-003

Imaprelimab (Anti-MUC18 / MCAM / CD146) is a humanized IgG1κ anti-melanoma cell adhesion molecule (MCAM) monoclonal antibody with antineoplastic activity. MW: 145.5 kD.

Imaprelimab (Anti-MUC18 / MCAM / CD146)

Quality Control

Batch: A239501 Purity: 99% Protein concentration: 10.45mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

Name Citation CD38 CD45 CD39 CD88 CD73 Others
RBN013209 0
MK-0159 0
CD38 inhibitor 1 (compound 78c) 7
AB680 1
NQ301 1 TXA2 receptor
SodiuM Metatungstate 3
PMX-53 3
LY-3475070 2
Expand to Check More
1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Imaprelimab (Anti-MUC18 / MCAM / CD146) is a humanized IgG1κ anti-melanoma cell adhesion molecule (MCAM) monoclonal antibody with antineoplastic activity. MW: 145.5 kD.

Product Details

CAS No. 2014343-04-3
Molecular Weight 145.5 kDa
Isotype Human IgG1
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07067255 RECRUITING Ovarian Cancer; Ovarian Carcinoma; Ovarian Sarcoma; Ovarian Cancer Stage IV Essen Biotech 2025-04-29 PHASE1; PHASE2
NCT07376291 NOT_YET_RECRUITING Exposure Occupational; Pulmonary Diseases Assistance Publique Hopitaux De Marseille 2026-06
NCT07066982 RECRUITING Sarcoma; Sarcoma, Kaposi; Sarcoma, Ewing; Sarcoma,Soft Tissue; Sarcoma of Bone and Connective Tissue; Sarcoma, Synovial; Sarcoma Metastatic; Sarcomas, Germinoblastic; Sarcoma of Bone Essen Biotech 2025-05-29 PHASE1; PHASE2
NCT07602335 NOT_YET_RECRUITING Drug: MCAM Opioid Use Disorder The University of Texas Health Science Center at San Antonio 2026-08-08 EARLY_PHASE1
NCT06001281 RECRUITING Glioblastoma Assistance Publique Hopitaux De Marseille 2024-01-30
NCT03341949 COMPLETED Chronic Renal Failure Assistance Publique Hopitaux De Marseille 2018-02-28

(data from https://clinicaltrials.gov, updated on 2025-07-16)

Tech Support

Handling Instructions

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