CAS No. 873225-46-8
Batch:
Purity:99.07
Chemical Structure
Check the
IKK-16
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [4-[[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]amino]phenyl]-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone | |
|---|---|---|
| CAS Number | 873225-46-8 | |
| Molecular Formula |
C28H29N5OS |
|
| Molecular Weight (MW) | 483.63 | |
| SMILES | C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5 | |
| InChIKey | BWZJBXAPRCVCKQ-UHFFFAOYSA-N |
Biological Activity
IKK-16 is a selective IκB kinase inhibitor that targets IKK-2, the IKK complex, and IKK-1. By blocking IKK-mediated phosphorylation, it prevents NF-κB signaling pathway activation and reduces downstream pro-inflammatory gene expression. Additionally, IKK-16 inhibits leucine-rich repeat kinase 2 (LRRK2) kinase activity and Ser935 phosphorylation in cells. Consequently, this compound serves as a valuable tool for investigating NF-κB and LRRK2 signaling mechanisms in inflammatory and neuronal cellular models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
97 mg/mL
(200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.