CAS No. 1805789-54-1

Batch: Purity:99.91
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Samuraciclib (ICEC0942) hydrochloride Chemical Structure
Chemical Structure
Check the Samuraciclib (ICEC0942) hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3R,4R)-4-[[[7-(benzylamino)-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol;hydrochloride
CAS Number 1805789-54-1
Molecular Formula

C22H31ClN6O
Molecular Weight (MW) 430.97
SMILES CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCC4CCNCC4O.Cl
InChIKey YMNPLAHCOLEZJE-ZFNKBKEPSA-N

Ordering Information

Biological Activity

Samuraciclib (ICEC0942) hydrochloride is an orally bioavailable cyclin-dependent kinase 7 (CDK7) inhibitor with an IC50 of 40 nM, displaying 45-, 15-, 230-, and 30-fold selectivity over CDK1, CDK2, CDK5, and CDK9, respectively. By inhibiting CDK7-mediated phosphorylation of RNA polymerase II and cell cycle CDKs, it suppresses gene transcription and cell cycle progression. Consequently, samuraciclib blocks cell proliferation and induces cell cycle arrest and apoptosis in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 86 mg/mL (199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 86 mg/mL
Ethanol 15 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.