Numerous clinical trials evaluate hyaluronic acid across diverse therapeutic and aesthetic applications, spanning early phase research through Phase 4 protocols funded by academic, government, and corporate sponsors. Key indications under investigation include dermatological conditions such as skin laxity, chin retrusion, and actinic keratoses, alongside knee osteoarthritis, thyroid eye disease, and interstitial lung disease. These studies feature recruitment statuses ranging from actively recruiting and enrolling by invitation to completed and terminated.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT07589959 | NOT_YET_RECRUITING | Periodontal Bone Loss; Periodontal Defect; Periodontitis Stage III; Periodontitis Stage IV |
Shashi Dadlani |
2026-05 | |
| NCT06685120 | RECRUITING | Osteo Arthritis Knee |
Istituto Ortopedico Rizzoli |
2025-12-11 | |
| NCT07255261 | RECRUITING | Lips Enhancement; Perioral Wrinkles; Nasolabial Fold Wrinkles; Cheek Augmentation; Infraorbital Hollows |
Symatese |
2025-07-02 | |
| NCT07631273 | NOT_YET_RECRUITING | Periodontitis; Diabetes Mellitus; Hyaluronic Acid; Oral Microbiota; IL-34; β-CTX |
Marmara University |
2026-06 | |
| NCT07714811 | RECRUITING | Tendinopathy; Enthesopathy; Achilles Tendinopathy; Golfer's Elbow; Medial Epicondylitis |
Ortonika Orthopedic Medical Clinic in Lublin |
2026-06-10 | |
| NCT07522684 | RECRUITING | Periodontitis |
University of Sao Paulo |
2026-02-25 | |
| NCT07750756 | NOT_YET_RECRUITING | Peri-implant Mucosa Thickness |
Ain Shams University |
2026-10-30 | PHASE2; PHASE3 |
| NCT07611630 | NOT_YET_RECRUITING | Periodontitis |
The First Affiliated Hospital of Xinxiang Medical College |
2026-05-01 | |
| NCT06522438 | RECRUITING | Periodontitis; Wound Heal; Periodontal Pocket; Periodontal Inflammation; Periodontal Attachment Loss |
Queen Mary University of London |
2025-06-03 | |
| NCT06237647 | RECRUITING | Rotator Cuff Lesions |
Tien-Ching Lee |
2023-02-17 | |
| NCT07697196 | NOT_YET_RECRUITING | HPV Infection; HPV Integration; HPV Disease; HPV Genital Infection; HPV Persistence; Low Grade Squamous Intraepithelial Lesions of the Cervix |
IRCCS San Raffaele |
2026-07 | |
| NCT07504250 | NOT_YET_RECRUITING | Dacryocystitis |
All India Institute of Medical Sciences, Bhubaneswar |
2026-04-01 | PHASE4 |
| NCT06878599 | NOT_YET_RECRUITING | Sudden Sensorineural Hearing Loss (SSNHL) |
Assiut University |
2025-05-01 | PHASE4 |
| NCT07320183 | NOT_YET_RECRUITING | HPV - Anogenital Human Papilloma Virus Infection; Infertilities |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2026-03-01 | |
| NCT07344337 | NOT_YET_RECRUITING | HPV Infection; Infertilities |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2026-03 | |
| NCT07529340 | NOT_YET_RECRUITING | Gingival Recession, Mucogingival Surgery |
Universidade do Porto |
2026-05 | |
| NCT07701863 | NOT_YET_RECRUITING | Atrophic Vaginitis; Atrophic Vulvovaginitis; Vaginal Atrophy; Dyspareunia; Vulvo Vaginal Atrophy; Vaginal Dryness |
Biovico Sp. z o.o. |
2026-07 | |
| NCT07339605 | RECRUITING | Guided Tissue Regeneration, Periodontal / Methods; Dental Enamel Proteins* / Therapeutic Use; Alveolar Bone Loss* / Therapy; Hyaluronic Acid* / Therapeutic Use; Humans; Intrabony Defect; Flapless |
University of Valencia |
2024-10-26 | |
| NCT07729514 | NOT_YET_RECRUITING | Subdeltoid Bursitis of the Shoulder |
Shin Kong Wu Ho-Su Memorial Hospital |
2026-08-01 | PHASE4 |
| NCT06310941 | NOT_YET_RECRUITING | Nosocomial Infection; Nosocomial Pneumonia; Tracheobronchitis; Mechanical Ventilation Complication; Endotracheal Intubation |
Hospital San Carlos, Madrid |
2026-01-01 | |
| NCT07792720 | RECRUITING | Partial Edentulism; Dental Implant Placement |
Samar Ali Abdu Salamah |
2025-06-05 | |
| NCT07680101 | NOT_YET_RECRUITING | Degenerative Joint Disease of Knee; Rheumatoid Arthritis |
Universita di Verona |
2026-06 | |
| NCT07542132 | NOT_YET_RECRUITING | Skin Health |
Hans Laubach |
2026-10 | |
| NCT07305519 | RECRUITING | Preterm Labor |
University of Roma La Sapienza |
2026-04-01 | |
| NCT07771244 | NOT_YET_RECRUITING | RT II Gingival Recession |
Cairo University |
2026-09-01 | |
| NCT07657247 | NOT_YET_RECRUITING | Nasal Dryness |
YSLab |
2026-12-15 | |
| NCT07737678 | NOT_YET_RECRUITING | Intrabony Periodontal Defect; Periodontal Disease |
Mansoura University |
2026-08-01 | PHASE1; PHASE2 |
| NCT07800676 | NOT_YET_RECRUITING | Knee Pain Chronic |
Taipei Medical University |
2026-09-01 | |
| NCT07441135 | RECRUITING | Aesthetic Body Volume Loss |
i+Med S.Coop. |
2026-02-18 | |
| NCT07614932 | NOT_YET_RECRUITING | TMJ Disc Disorder; Temporomandibular Joint Disc Displacement, Without Reduction; TMD/Orofacial Pain; Temporomandibular Disorder; TMJ Closed Lock |
Cairo University |
2026-05 | |
| NCT07763990 | RECRUITING | Lips Enhancement Nasolabial Fold Correction Midface Volume Deficit |
Hallura Ltd. |
2023-01-09 | |
| NCT07729527 | NOT_YET_RECRUITING | Subdeltoid Bursitis of the Shoulder |
Shin Kong Wu Ho-Su Memorial Hospital |
2026-07-31 | |
| NCT07380867 | ENROLLING_BY_INVITATION | Colorectal Cancer; Endoscopic Tattoo of Suspected Colon Cancer; Indocyanine Green (ICG) |
Seoul St. Mary's Hospital |
2025-12-22 | |
| NCT06897085 | NOT_YET_RECRUITING | Periodontitis; Gingival Recession, Localized; Aesthetic Perception; Aesthetic Outcomes |
Azienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, Italy |
2025-04-01 | |
| NCT06376981 | RECRUITING | Shoulder Tendinitis |
Centre Hospitalier Departemental Vendee |
2024-09-19 | PHASE3 |
| NCT07236632 | NOT_YET_RECRUITING | Premature Ejaculation |
Benha University |
2025-12-15 | |
| NCT07520539 | NOT_YET_RECRUITING | Single RT1 Gingival Recession With no Loss of Interproximal Attachment |
Cairo University |
2026-07-01 | PHASE1; PHASE2 |
| NCT07666347 | RECRUITING | Intraarticular Injection; Botox; Hyaluronic Acid; Knee Osteoarthritis |
Tanta University |
2026-06-24 | |
| NCT07458334 | RECRUITING | Skin Biophysical Properties |
Kaohsiung Medical University Chung-Ho Memorial Hospital |
2026-02-09 | |
| NCT07495072 | RECRUITING | Urinary Bladder Neoplasms; BCG-Induced Cystitis |
BLAD-HYA Group |
2025-11-03 | |
| NCT07683650 | RECRUITING | TMJ Disc Displacement With Reduction |
Mansoura University |
2026-01-06 | |
| NCT06587880 | RECRUITING | Extraction Socket Healing; Quality of Life; Postoperative Complications |
University of Jordan |
2025-08-10 | PHASE4 |
| NCT07658118 | NOT_YET_RECRUITING | Cystitis, Interstitial; Chronic Pain |
Sverdlovsk Regional Clinical Hospital No.1 |
2026-07 | PHASE1 |
| NCT07662226 | NOT_YET_RECRUITING | Plaque Induced Gingival Disease |
Cairo University |
2026-08-01 | PHASE1 |
| NCT07708051 | NOT_YET_RECRUITING | Gingival Recession, Generalized; Gingival Recession, Localized; Wound Healing; Palate; Wound |
University of Sao Paulo |
2026-07 | |
| NCT06653985 | RECRUITING | Osteoarthritis; Femoroacetabular Impingement Syndrome; Labrum Injury of the Hip Joint |
ArthroBiologix Inc. |
2024-05-01 | |
| NCT07102225 | ACTIVE_NOT_RECRUITING | Mild to Moderate Knee OA |
Bangladesh Medical University |
2025-05-04 | PHASE3 |
| NCT06984107 | NOT_YET_RECRUITING | Medication Related Osteonecrosis of the Jaw |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2025-09-01 | |
| NCT05408065 | RECRUITING | Infiltration; Shoulder Osteoarthritis |
Centre hospitalier de l'Université de Montréal (CHUM) |
2022-11-15 | |
| NCT07683351 | RECRUITING | Palatal Wound Healing; Mucogingival Defects; Free Gingival Graft Donor Site |
Suez Canal University |
2025-08-27 | |
| NCT07735806 | COMPLETED | Impacted Mandibular Third Molar |
Kafrelsheikh University |
2024-07-22 | |
| NCT07595757 | ACTIVE_NOT_RECRUITING | Periodontal Disease; Periodontitis |
Cairo University |
2025-07-15 | PHASE1; PHASE2 |
| NCT07367087 | NOT_YET_RECRUITING | Partial-Thickness Burn, Thermal Burn |
Dr Muhammad Naveed Shahzad |
2026-02 | |
| NCT07746206 | RECRUITING | Treatment of Stage III Periodontitis; Local Application of Insulin in Pockets |
Doaa Atta Aid |
2026-07-24 | EARLY_PHASE1 |
| NCT07700732 | ACTIVE_NOT_RECRUITING | Tooth Loss; Surface Treatment; Delayed Implant; Implant Placement; UV Dental Implant; Hyaluronic Acid (HA) |
Mansoura University |
2025-10-01 | |
| NCT07044219 | NOT_YET_RECRUITING | Dry Socket; Postoperative Infections |
University of Pecs |
2025-07-01 | |
| NCT07709455 | COMPLETED | Traumatic Oral Ulceration; Orthodontic Treatment; Orthodontic Appliances, Fixed; Oral Mucosal Ulceration |
Dow University of Health Sciences |
2026-01-10 | |
| NCT07547956 | RECRUITING | Atrophic Acne Scars |
Cairo University |
2025-10-20 | |
| NCT06914518 | NOT_YET_RECRUITING | Peri-implantitis |
Universitat Internacional de Catalunya |
2025-09-20 | |
| NCT06983015 | NOT_YET_RECRUITING | Socket Preservation |
Fayoum University |
2025-06 | |
| NCT07421544 | NOT_YET_RECRUITING | Fine Lines; Wrinkle; Facial Laxity; Volume Loss |
Goldman, Butterwick, Fitzpatrick and Groff |
2026-03-01 | PHASE4 |
| NCT07040631 | COMPLETED | Breast Cancer; Postoperative Sore Throat, Cough, Hoarseness; Endotracheal Intubation; General Anesthesia |
Pusan National University Yangsan Hospital |
2025-08-06 | |
| NCT07031895 | NOT_YET_RECRUITING | Socket Preservation |
TC Erciyes University |
2025-09-02 | |
| NCT07153237 | ACTIVE_NOT_RECRUITING | Aging; Aesthetic |
Laboratoires Vivacy |
2025-09-09 | |
| NCT07750483 | COMPLETED | Temporomandibular Joint Internal Derangement |
Mansoura University |
2025-04-01 | |
| NCT06611631 | NOT_YET_RECRUITING | Pulpotomies Primary Teeth; Pulp Disease, Dental |
Cairo University |
2025-03 | PHASE1 |
| NCT07715331 | COMPLETED | Excessive Gingival Display; Gingival Diseases; Gummy Smile; Esthetics, Dental |
Al-Azhar University |
2025-01-01 | |
| NCT07376148 | RECRUITING | Skin Quality Improvement; Photo-aged Skin; Drug Delivery Systems |
Instituto de Oftalmología Fundación Conde de Valenciana |
2025-11-07 | PHASE4 |
| NCT07169357 | ENROLLING_BY_INVITATION | Gingival Hyperplasia; Gingival Hypertrophy; Gingival Overgrowth; Gingival Enlargement; Photobiomodulation Therapy; Low-level-laser Theraphy |
Beirut Arab University |
2025-11-11 | EARLY_PHASE1 |
| NCT07291583 | COMPLETED | Gingival Recession |
Saglik Bilimleri Universitesi |
2025-07-01 | |
| NCT06694532 | RECRUITING | Temporomandibular Joint Disorders; Arthrocentesis |
Basel khaled mohamed |
2023-10-31 | PHASE1; PHASE2 |
| NCT07202390 | NOT_YET_RECRUITING | Knee Osteoarthritis |
Northern Orthopaedic Division, Denmark |
2026-02-01 | |
| NCT05825170 | RECRUITING | Lip, Cleft; Lip Scar |
Symatese |
2023-12-08 | |
| NCT07221461 | NOT_YET_RECRUITING | Wrinkle |
Goldman, Butterwick, Fitzpatrick and Groff |
2025-11-01 | PHASE2 |
| NCT06582004 | ACTIVE_NOT_RECRUITING | Cervical Intraepithelial Neoplasia; Human Papillomavirus |
National Taiwan University Hospital |
2024-09-30 | |
| NCT06985875 | NOT_YET_RECRUITING | Eye Dryness |
Avizor SA |
2025-07 | PHASE3 |
| NCT07309588 | ENROLLING_BY_INVITATION | Xerostomia Due to Hyposecretion of Salivary Gland |
Poznan University of Medical Sciences |
2025-07-01 | PHASE1; PHASE2 |
| NCT07205640 | NOT_YET_RECRUITING | Mesh; Healthy Volunteer; Low Level Laser Therapy; Hyaluronic Acid Gel for Preservation the Extraction Socket; Extraction Socket Healing; Badly Decayed Molars; Tooth Extraction Site Healing |
Cairo University |
2025-12-01 | |
| NCT05591651 | UNKNOWN | Cracked Nipple; Breastfeeding; Healing Wound |
Specijalisticka Pedijatrijska Ordinacija prim.mr.sc. Maja Stimac, Specijalist Pedijatrije Sspecijalnosti Neonatologije |
2023-01-09 | PHASE4 |
| NCT06879938 | RECRUITING | Genitourinary Syndrome of Menopause |
Fondazione IRCCS Policlinico San Matteo di Pavia |
2023-10-16 | |
| NCT06994546 | RECRUITING | Knee Osteoarthristis |
Maxigen Biotech Inc. |
2025-03-11 | |
| NCT06865092 | COMPLETED | Gingival Overgrowth |
Saglik Bilimleri Universitesi |
2023-05-01 | |
| NCT06822608 | NOT_YET_RECRUITING | Corneal Epithelial Wound Healing |
National and Kapodistrian University of Athens |
2025-02 | PHASE4 |
| NCT06633211 | NOT_YET_RECRUITING | Bone Substitutes; Tooth Extraction Status Nos |
Adrià Jorba García |
2024-10-15 | |
| NCT07023822 | COMPLETED | Breast Cancer; Vulvovaginal Signs and Symptoms; Sexual Desire Disorder; Body Image |
The University of Tennessee, Knoxville |
2025-06-16 | |
| NCT07081230 | RECRUITING | Periodontitis |
husain abduljalil alam |
2025-07-07 | |
| NCT06156488 | COMPLETED | Sinus Floor Augmentation |
Universidad de Granada |
2023-09-04 | |
| NCT07031388 | COMPLETED | Plaque Induced Gingival Disease |
Ramziyah Hayder Bakr |
2025-07-01 | |
| NCT07571265 | COMPLETED | Temporomandibular Arthritis |
Cairo University |
2024-05-01 | |
| NCT07233226 | COMPLETED | Tympanoplasty |
Mansoura University |
2023-01-25 | |
| NCT07108400 | RECRUITING | Hip Osteoarthritis |
De Sire Alessandro |
2022-03-17 | |
| NCT07479693 | COMPLETED | Temporomandibular Joint Pain; Arthrocentesis |
Ondokuz Mayıs University |
2025-01-01 | |
| NCT05824806 | UNKNOWN | Osteoarthritis, Knee |
Instituto Nacional de Traumatologia e Ortopedia |
2024-08 | PHASE3 |
| NCT07563790 | COMPLETED | GERD (Heartburn, Regurgitation, and Dyspepsia); Gastroesophageal Reflux (GERD) |
Rose Pharma SA |
2024-07-24 | |
| NCT05936437 | COMPLETED | Atrophic Scar |
Mastelli S.r.l |
2023-11-16 | |
| NCT07078474 | COMPLETED | Skin Hydration; Hyaluronic Acid |
University of Split, School of Medicine |
2025-06-18 | |
| NCT07468045 | COMPLETED | Arthroscopic Surgery |
Daewoong Group Indonesia |
2024-10-09 | |
| NCT07510295 | COMPLETED | Atrophic Acne Scars |
Ngô Anh Tuấn |
2025-01-17 | |
| NCT06774742 | COMPLETED | Skin Quality; Lips Quality; Persistence of the Effect |
TS Biotech - Shandong Tiansheng Biotechnology Co., Ltd |
2025-01-02 | |
| NCT07183436 | COMPLETED | Adhesive Capsulitis of the Shoulder |
Mahidol University |
2023-11-01 | PHASE3 |
| NCT05937100 | ACTIVE_NOT_RECRUITING | Carious Exposure of Pulp |
Mansoura University |
2023-05-01 | |
| NCT06506656 | UNKNOWN | Degenerative Joint Disease |
University of Roma La Sapienza |
2024-07-16 | |
| NCT05414253 | ACTIVE_NOT_RECRUITING | Wound Heal; Surgical Wound; Impacted Third Molar Tooth |
University of Pisa |
2022-06-01 | |
| NCT05687019 | COMPLETED | Prostatic Adenoma |
GCS Ramsay Santé pour l'Enseignement et la Recherche |
2023-09-12 | |
| NCT07034625 | COMPLETED | Gingival Enlargement |
Akdeniz University |
2024-06-01 | |
| NCT06976866 | ACTIVE_NOT_RECRUITING | In Recent Years, There Has Been a Rise in the Use of Immediate Loading Protocols; Dental Implant Stability |
Amira attia |
2023-07-13 | |
| NCT07089446 | COMPLETED | Knee Osteoarthristis |
University of Karachi |
2022-09-21 | |
| NCT06937645 | RECRUITING | Infertile Patients |
Al-Nahrain University |
2023-09-01 | PHASE2 |
| NCT06775314 | NOT_YET_RECRUITING | Acne Vulgaris |
Dr.dr.Irma Bernadette, SpKK (K) |
2025-03-01 | PHASE3 |
| NCT05086939 | ACTIVE_NOT_RECRUITING | Knee Osteoarthritis |
Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León |
2021-05-26 | PHASE3 |
| NCT07126912 | RECRUITING | Mid Face Volume Deficit |
Espad Pharmed |
2025-01-28 | |
| NCT04671914 | UNKNOWN | Asherman Syndrome; Abortion Late |
Institute for the Care of Mother and Child, Prague, Czech Republic |
2021-09-28 | PHASE4 |
| NCT06446843 | COMPLETED | Internal Derangement |
Cairo University |
2024-09-18 | |
| NCT06351293 | COMPLETED | Wrinkle |
Galderma R&D |
2024-02-21 | |
| NCT06872151 | COMPLETED | Anus Diseases; Gastrointestinal Diseases; Intestinal Diseases; Cicatrization; Hemorrhoids; Hemorrhoids Third Degree |
University of Cagliari |
2025-03-04 | PHASE4 |
| NCT06783517 | ACTIVE_NOT_RECRUITING | Effect of Putty Form Bone Graft in Immediate Implant Placment |
Mansoura University |
2023-10-30 | |
| NCT06238934 | NOT_YET_RECRUITING | Knee Osteoarthritis |
Instituto Nacional de Traumatologia e Ortopedia |
2024-03 | PHASE3 |
| NCT07473453 | COMPLETED | Peridontal Disease |
Aristotle University Of Thessaloniki |
2024-04-16 | |
| NCT07033312 | COMPLETED | Knee Osteoarthritis |
Taichung Veterans General Hospital |
2023-04-21 | |
| NCT06279507 | UNKNOWN | Knee Osteoarthritis; Pain, Joint; Stiffness of Knee, Not Elsewhere Classified; Quality of Life |
Phramongkutklao College of Medicine and Hospital |
2024-02-10 | PHASE4 |
| NCT06508125 | UNKNOWN | Subdeltoid Bursitis; Hyaluronic Acid |
Taipei Medical University |
2024-07-25 | PHASE4 |
| NCT06077981 | RECRUITING | Esophageal Neoplasms; Endoscopic Mucosal Resection; Hyaluronic Acid |
Instituto do Cancer do Estado de São Paulo |
2023-06-19 | |
| NCT07110402 | COMPLETED | Osteoarthritis, Knee; Chondral Defect; Chondromalacia, Left Knee; Chondromalacia, Right Knee; Articular Cartilage Disorder of Knee |
eMKa MED Medical Center |
2022-12-12 | |
| NCT06209879 | UNKNOWN | Dry Eye Syndromes |
Chang Gung Memorial Hospital |
2024-02-05 | PHASE4 |
| NCT05869136 | UNKNOWN | Thin-gingiva |
Postgraduate Institute of Dental Sciences Rohtak |
2023-10-16 | |
| NCT07421934 | TERMINATED | Post-surgical Oral Wounds; Oral Cavity Surgery; Wound Healing/Regeneration; Dental Extraction Sites; Alveolar Socket Recovery; Post-extractive Inflammation |
The Wave Innovation Group s.r.l. |
2024-10-29 | |
| NCT05613075 | COMPLETED | Alveolar Bone Resorption; Socket Preservation; Bone Resorption; Unrestorable Dentition |
Cairo University |
2022-12-01 | |
| NCT05450458 | COMPLETED | Overuse Injury; Body Mass Index in Athletes |
Hospital Regional Tlalnepantla |
2023-02-01 | PHASE2; PHASE3 |
| NCT06844760 | COMPLETED | Skin Aging |
Espad Pharmed |
2024-07-04 | |
| NCT06544447 | UNKNOWN | Dry Eye |
Beijing Tongren Hospital |
2021-06-01 | PHASE1; PHASE2 |
| NCT04673643 | RECRUITING | Dry Eye Disease |
Beijing Tongren Hospital |
2021-07-01 | PHASE2 |
| NCT06538818 | COMPLETED | Mastectomy; Carpal Tunnel Syndrome (CTS) |
Cairo University |
2024-09-01 | |
| NCT06290219 | UNKNOWN | Traumatic Olfactory Nerve Injury With Anosmia (Diagnosis); Effect of Drug |
Taichung Veterans General Hospital |
2024-03-20 | PHASE3 |
| NCT07789860 | COMPLETED | Temporomandibular Joint Internal Derangement |
Suez Canal University |
2023-09-30 | PHASE3 |
| NCT05370456 | UNKNOWN | Gingival Recession, Generalized |
University of Turin, Italy |
2022-05-03 | |
| NCT06425263 | UNKNOWN | Temporomandibular Joint Osteoarthritis |
Cairo University |
2024-06-01 | |
| NCT05700253 | UNKNOWN | Osteoarthritis, Knee; Pain |
Changi General Hospital |
2023-02 | |
| NCT06543199 | COMPLETED | Wound Healing Disorder; Palate; Wound |
Ataturk University |
2024-01-02 | |
| NCT05983081 | COMPLETED | Adhesive Capsulitis |
Tri-Service General Hospital (TSGH) |
2023-08-01 | |
| NCT05962619 | UNKNOWN | Temporomandibular Joint Dysfunction Syndrome; Arthrocenteses; Hyaluronic Acid |
Assiut University |
2023-08-01 | |
| NCT06284538 | UNKNOWN | Wound Healing Disorder |
Nova Argentia S.r.l. |
2024-01-15 | |
| NCT06530745 | COMPLETED | Temporomandibular Joint Disorders; Temporomandibular Joint Pain |
Hospital of the Ministry of Interior, Kielce, Poland |
2024-07-18 | PHASE4 |
| NCT06605768 | COMPLETED | Hair Thinning |
Nutra Harmony LLC |
2024-02-19 | |
| NCT06710782 | COMPLETED | Transcutaneous; Pulsed Radiofrequency; Genicular Nerve Block; Intraarticular; Hyaluronic Acid; Chronic Pain; Knee Osteoarthritis |
Tanta University |
2023-08-01 | |
| NCT06176820 | UNKNOWN | Menopause Related Conditions; Atrophic Vaginitis; Genitourinary Syndrome of Menopause; Sexual Dysfunction |
Sarawak General Hospital |
2024-01-01 | PHASE2; PHASE3 |
| NCT06189456 | UNKNOWN | Dry Eye Syndrome (DES) |
Fidia Farmaceutici s.p.a. |
2023-06-21 | |
| NCT06426199 | UNKNOWN | TMJ Disc Disorder |
Ain Shams University |
2024-01-17 | PHASE4 |
| NCT06457698 | UNKNOWN | Temporomandibular Joint Disorders |
Instituto Portugues da Face |
2022-06-01 | |
| NCT06447311 | UNKNOWN | Gingival Destruction |
Dr R Viswa Chandra |
2023-04-10 | |
| NCT06431282 | UNKNOWN | Aging Skin |
Universitätsklinikum Hamburg-Eppendorf |
2024-02-20 | |
| NCT06842511 | COMPLETED | Periodontitis (Stage 3) |
Ordu University |
2023-04-04 | PHASE1; PHASE2 |
| NCT05871177 | COMPLETED | Peyronie Disease |
IBSA Farmaceutici Italia Srl |
2023-05-21 | |
| NCT06098456 | COMPLETED | Papilloma-induced Cervical Lesions |
Centro di Ricerca Clinica Salentino |
2023-11-01 | PHASE2 |
| NCT06325696 | Not yet recruiting | Interstitial Lung Disease|Idiopathic Pulmonary Fibrosis|Lung Diseases Interstitial |
National Institute of Environmental Health Sciences (NIEHS)|National Institutes of Health Clinical Center (CC) |
2024-05-15 | Phase 2 |
| NCT06637384 | COMPLETED | Diabetes Mellitus; Wound Healing Delayed |
Rimsha Rasheed |
2024-03-01 | PHASE4 |
| NCT07742241 | COMPLETED | Atopic Dermatitis (AD) |
Instituto de Investigacion Biotecnologica, Farmaceutica y Medicamentos Huerfanos, S.L. |
2023-01-09 | |
| NCT05130814 | COMPLETED | Pressure Sore; Pressure Ulcer; Pressure Ulcers Stage III; Pressure Ulcers Stage II |
Emoled |
2021-12-01 | |
| NCT06517667 | COMPLETED | Dry Eye |
University of Seville |
2023-11-01 | PHASE2; PHASE3 |
| NCT06156722 | UNKNOWN | Fertility Issues |
Meir Medical Center |
2019-03-01 | |
| NCT06309797 | COMPLETED | Periodontitis |
Özlem SARAÇ ATAGÜN |
2023-05-02 | |
| NCT07071467 | COMPLETED | Periodontitis (Stage 3); Periodontitis |
Karim Ismail |
2023-09-01 | |
| NCT05990049 | UNKNOWN | Hyaluronic Acid; Gingival Recession, Localized; Pain, Postoperative |
University of Zagreb |
2023-03-01 | PHASE3 |
| NCT05803083 | COMPLETED | Healthy Japanese Subjects |
Bloomage Biotechnology Corp., Ltd. |
2023-02-06 | |
| NCT06797167 | COMPLETED | Atrophy Vulva |
Rose Pharma SA |
2022-04-08 | |
| NCT05682833 | UNKNOWN | Periodontitis; Hyaluronic Acid; Chlorhexidine |
University of Sharjah |
2022-10-01 | |
| NCT06332365 | COMPLETED | Oral Lichen Planus; Oral Lichen Planus Related Stress |
Pia Lopez Jornet |
2022-01-03 | |
| NCT05027581 | COMPLETED | Osteoarthritis, Knee |
Taiwan Bio Therapeutics Inc. |
2021-10-13 | PHASE2 |
| NCT05853224 | UNKNOWN | Dermal Filler; Volume Deficiency of the Midface |
Biopolimeri Srl |
2022-04-02 | |
| NCT05198544 | UNKNOWN | Diabetic Foot |
SerenaGroup, Inc. |
2023-06-01 | |
| NCT05994638 | UNKNOWN | Oral Mucositis |
AronPharma Sp. z o. o. |
2023-08-21 | |
| NCT06509477 | COMPLETED | Moderate or Severe Nasolabial Folds |
Espad Pharmed |
2021-12-01 | |
| NCT06243744 | Recruiting | Skin Laxity|Tissue Degeneration|Tissue Breakdown|Collagen Degeneration|Collagen Shrinkage |
Apyx Medical |
2023-11-30 | Not Applicable |
| NCT05690100 | UNKNOWN | Palate; Wound |
Cairo University |
2023-01 | |
| NCT04766918 | COMPLETED | Carpal Tunnel Syndrome |
Tri-Service General Hospital (TSGH) |
2021-08-01 | |
| NCT06012370 | UNKNOWN | Stress Incontinence, Female |
Kasr El Aini Hospital |
2023-09-01 | |
| NCT06438354 | COMPLETED | Periodontal Pocket |
University of Witten/Herdecke |
2022-08-01 | PHASE4 |
| NCT05888116 | COMPLETED | Vaginal Disease |
Dermofarm, S.A.U |
2023-05-23 | |
| NCT05622851 | COMPLETED | Volume Deficiency of the Midface |
Galderma R&D |
2022-07-12 | |
| NCT05291650 | COMPLETED | Osteoarthritis, Knee |
Zhujiang Hospital |
2022-04-25 | PHASE4 |
| NCT05345093 | COMPLETED | Acne Vulgaris; Folliculitis |
BMG Pharma |
2022-11-11 | |
| NCT06144814 | COMPLETED | Vulvovaginal Atrophy |
Koru Health Groups |
2023-04-05 | |
| NCT05851560 | COMPLETED | Thyroidectomy; Goiter; Thyroid Cancer |
National Taiwan University Hospital |
2023-05-24 | PHASE1 |
| NCT05161403 | UNKNOWN | Wound Heal |
Cairo University |
2022-02-22 | |
| NCT06050837 | Not yet recruiting | High Risk Esophageal Varices |
Institute of Liver and Biliary Sciences India |
2023-09-30 | -- |
| NCT05746676 | UNKNOWN | Periodontal Diseases; Periodontal Pocket |
October University for Modern Sciences and Arts |
2023-01-12 | PHASE3 |
| NCT05450380 | COMPLETED | Skin Folds; Wrinkle |
Mesoestetic Pharma Group S.L. |
2022-08-02 | |
| NCT06451822 | COMPLETED | Skin Aging; Skin Wrinkling |
Mesoestetic Pharma Group S.L. |
2022-02-03 | |
| NCT06307041 | COMPLETED | Gingivitis |
Özlem SARAÇ ATAGÜN |
2023-04-03 | |
| NCT06221345 | COMPLETED | Dry Eye Disease; Cataract |
Chang Gung Memorial Hospital |
2021-12-07 | PHASE4 |
| NCT04373603 | WITHDRAWN | Injection Site Bruising |
University of Wisconsin, Madison |
2022-07 | PHASE4 |
| NCT05682547 | COMPLETED | Diabetic Eye Problems |
He Eye Hospital |
2022-12-01 | |
| NCT05823961 | COMPLETED | Dry Eye Disease; Dry Eye; Kerato Conjunctivitis Sicca |
C.O.C. Farmaceutici S.r.l. |
2022-06-10 | |
| NCT07130266 | COMPLETED | Hyaluronic Acid; Open Flap Debridement; Periodontitis; Gingival Phenotype; Gingival Recession |
Bezmialem Vakif University |
2022-05-09 | |
| NCT05807360 | COMPLETED | Dry Eye; Dry Eye Disease; Kerato Conjunctivitis Sicca |
C.O.C. Farmaceutici S.r.l. |
2022-06-24 | |
| NCT06451406 | COMPLETED | Selective Serotonin Reuptake Inhibitor; Hyaluronic Acid; Glans Penis; Lifelong Premature |
New Valley University |
2022-10-01 | |
| NCT05060744 | UNKNOWN | Oesophageal Reflux; Gastric Reflux; Hyperactivity; Stomach |
Uriach Consumer Healthcare |
2021-09-09 | |
| NCT05561179 | UNKNOWN | Gastroesophageal Reflux |
Instituto Ecuatoriano de Enfermedades Digestivas |
2022-09-30 | |
| NCT05295680 | Recruiting | Primary Sclerosing Cholangitis |
Aparna Goel|Stanford University |
2023-05-10 | Phase 2 |
| NCT05694286 | COMPLETED | Dermal Filler; Rejuvenation |
University of Pennsylvania |
2023-01-06 | |
| NCT05730543 | COMPLETED | Lip Augmentation; Lip Fullness |
DeNova Research |
2022-11-01 | PHASE3 |
| NCT05787600 | COMPLETED | Plaque Induced Gingivitis; Mouth Diseases; Bleeding Gum; Periodontal Diseases |
University of Baghdad |
2023-03-03 | PHASE3 |
| NCT04766853 | COMPLETED | Hearing Loss, Sudden; Hearing Loss, Ototoxic; Hearing Loss, Noise-Induced; Meniere Disease |
Seoul National University Hospital |
2021-07-22 | PHASE1; PHASE2 |
| NCT06777199 | COMPLETED | Premature Ejaculation |
Ahmed Hamdy Ahmed |
2022-07-01 | |
| NCT07199725 | COMPLETED | Dental Implants |
Suez Canal University |
2022-11-08 | PHASE2; PHASE3 |
| NCT05818007 | COMPLETED | Oral Mucositis |
Yuzuncu Yil University |
2022-04-01 | PHASE4 |
| NCT05543434 | UNKNOWN | Periodontal Diseases |
Cairo University |
2022-12-01 | |
| NCT05252325 | UNKNOWN | Nasolabial Folds |
Centro Medico Polispecialistico |
2022-02 | |
| NCT07285746 | ACTIVE_NOT_RECRUITING | Rotator Cuff Tear |
Hallym University Dongtan Sacred Heart Hospital |
2020-03-02 | |
| NCT05783479 | COMPLETED | Uterine Polyp; Uterine Bleeding; Endometrium; Senility |
Jagiellonian University |
2022-06-01 | |
| NCT06069453 | TERMINATED | Non-muscle Invasive Bladder Cancer (NMIBC) |
Fidia Farmaceutici s.p.a. |
2020-08-19 | |
| NCT05436288 | COMPLETED | Persistent Corneal Epithelial Defect |
Kiora Pharmaceuticals, Inc. |
2022-07-01 | PHASE2 |
| NCT06433492 | COMPLETED | Osteoarthritis, Knee |
Biovico Sp. z o.o. |
2020-12-30 | |
| NCT05239130 | UNKNOWN | Cicatrix; Lipodystrophy; Plaque |
I.R.A. Istituto Ricerche Applicate S.p.A. |
2022-03-21 | |
| NCT05834517 | COMPLETED | Periodontitis |
Ehab Haider Hassan El-emam |
2022-05-02 | PHASE4 |
| NCT04202692 | COMPLETED | Gastro Esophageal Reflux |
SOFAR S.p.A. |
2019-11-05 | |
| NCT05312593 | COMPLETED | Peri-implant Mucositis |
University of Pavia |
2022-04-05 | |
| NCT05312606 | COMPLETED | Periodontal Diseases |
University of Pavia |
2022-04-04 | |
| NCT05881330 | COMPLETED | Hyaluronic Acid |
Maxigen Biotech Inc. |
2021-07-01 | |
| NCT05045586 | UNKNOWN | Gingival Recession |
Medical University of Warsaw |
2021-09-15 | |
| NCT05412745 | COMPLETED | Cicatrix; Post-Surgical Complication; Scar Itching; Keloid; Hypertrophic Scar |
University of Rome Tor Vergata |
2022-05-01 | |
| NCT05263102 | COMPLETED | Menopause Syndrome |
HAN Biomedical Inc |
2020-03-01 | |
| NCT04971876 | COMPLETED | Lips Enhancement; Nasolabial Fold Correction; Midface Volume Deficit |
Hallura Ltd. |
2020-10-27 | |
| NCT05936762 | COMPLETED | Osteoarthritis of Knee |
Nextrasearch S.r.l.s. |
2021-08-31 | PHASE4 |
| NCT04975373 | UNKNOWN | Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel |
Barzilai Medical Center |
2021-06-25 | |
| NCT05768243 | COMPLETED | Periodontitis Chronic Generalized Severe |
Beirut Arab University |
2021-03-01 | PHASE4 |
| NCT05953896 | COMPLETED | Gingival Papillary Cratering |
Aya Elleithy |
2022-01-10 | |
| NCT05239351 | COMPLETED | Cicatrix; Lipodystrophy; Plaque |
I.R.A. Istituto Ricerche Applicate S.p.A. |
2022-03-07 | |
| NCT04839692 | COMPLETED | Lip Aging; Lip Augmentation; Lip |
Dieter Manstein, MD |
2021-05-07 | PHASE4 |
| NCT04874285 | COMPLETED | Pregnancy, High Risk |
Lo.Li.Pharma s.r.l |
2021-05-03 | |
| NCT04702399 | UNKNOWN | Patients With an Indication for Myomectomy or Polymyomectomy |
Assistance Publique - Hôpitaux de Paris |
2021-02-01 | |
| NCT06984419 | COMPLETED | Aesthetic; Aesthetic Rejuvenation; Midface Volumization; Age-related Volume Deficit in the Mid-face |
Institute Hyalual GmbH |
2021-06-29 | |
| NCT06176937 | COMPLETED | Hyaluronic Acid Gel for Preservation the Extraction Socket |
Ain Shams University |
2021-10-13 | PHASE4 |
| NCT04315415 | COMPLETED | Vocal Fold Palsy; Vocal Cord Paralysis; Vocal Cord Atrophy |
Sofregen Medical, Inc. |
2020-01-15 | |
| NCT04812457 | COMPLETED | Nails, Ingrown; Hyaluronic Acid |
University of Malaga |
2021-03-06 | EARLY_PHASE1 |
| NCT07476508 | COMPLETED | Meniscus Lesion; Knee Injuries; Medial Meniscus Tear |
Collegium Medicum w Bydgoszczy |
2019-10-10 | |
| NCT02459392 | COMPLETED | Lumbar Spinal Stenosis |
EPC Education s.r.o. |
2021-12-31 | |
| NCT04681937 | UNKNOWN | Partial Tear of Rotator Cuff; Rotator Cuff Tears |
Bezmialem Vakif University |
2021-06-01 | |
| NCT06043544 | COMPLETED | Glenohumeral Osteoarthritis |
Concordia Hospital Rome |
2021-05-02 | PHASE4 |
| NCT04692558 | UNKNOWN | Gingival Recession |
Krishnadevaraya College of Dental Sciences & Hospital |
2020-01-02 | PHASE4 |
| NCT04662216 | COMPLETED | Periodontitis |
Lithuanian University of Health Sciences |
2019-10-04 | |
| NCT04219722 | COMPLETED | Vulvovaginal Atrophy |
Laboratoires Vivacy |
2020-01-21 | |
| NCT03883074 | COMPLETED | Gastro Esophageal Reflux |
SOFAR S.p.A. |
2018-12-20 | |
| NCT04586361 | UNKNOWN | PRP; ACL; Hyaluronic Acid |
Kaohsiung Veterans General Hospital. |
2020-10-15 | PHASE4 |
| NCT04631263 | COMPLETED | Chin Augmentation and Correction |
Galderma R&D |
2021-01-29 | |
| NCT01738243 | TERMINATED | Thyroid Eye Disease |
University of California, Los Angeles |
2013-12 | PHASE4 |
| NCT05001243 | UNKNOWN | Presbyopia |
Optall Vision |
2021-08-10 | PHASE1 |
| NCT06034626 | COMPLETED | MGD-Meibomian Gland Dysfunction |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2020-11-03 | PHASE3 |
| NCT02793739 | COMPLETED | Personal Satisfaction |
Marmur Medical |
2016-09 | |
| NCT04986644 | COMPLETED | Refractive Error - Myopia Bilateral |
Vision Service Plan |
2021-05-10 | |
| NCT05781529 | COMPLETED | Alveolar Ridge Enlargement |
Ain Shams University |
2019-03-06 | |
| NCT04865952 | COMPLETED | Wound Heal; Wound Surgical; Oral Soft Tissue Conditions; Hyaluronic Acid |
University of Roma La Sapienza |
2021-04-29 | |
| NCT04638816 | COMPLETED | Cheek Augmentation |
Galderma R&D |
2021-04-16 | |
| NCT03290365 | COMPLETED | Knee Osteoarthritis |
Tri-Service General Hospital (TSGH) |
2018-01-10 | |
| NCT04467736 | COMPLETED | Healing Wound |
University Hospital, Ghent |
2020-08-01 | |
| NCT04358055 | COMPLETED | Nose Dry Feeling of |
Fidia Farmaceutici s.p.a. |
2020-01-31 | |
| NCT04816253 | COMPLETED | Preventing Postextraction Complication |
Al-Azhar University |
2021-02-10 | |
| NCT04117893 | COMPLETED | Osteoarthritis, Knee; Chronic Pain |
Beijing Tiantan Hospital |
2019-10-01 | PHASE4 |
| NCT04443166 | UNKNOWN | Osteoarthritis Knees Both |
Taipei Medical University WanFang Hospital |
2020-06 | |
| NCT03431584 | COMPLETED | Rhizarthrosis |
Centre Hospitalier Departemental Vendee |
2018-05-11 | PHASE4 |
| NCT05002036 | COMPLETED | Dry Eye Syndromes |
University of Milan |
2021-02-01 | PHASE4 |
| NCT04421300 | COMPLETED | Dry Eye; Keratoconjunctivitis Sicca; Eye Diseases; Corneal Diseases; Conjunctival Diseases |
Zhongshan Ophthalmic Center, Sun Yat-sen University |
2020-07-02 | |
| NCT05782920 | COMPLETED | Genitourinary Syndrome of Menopause |
Alexandria University |
2020-06-30 | |
| NCT03328728 | UNKNOWN | Knee Osteoarthritis |
Regen Lab SA |
2017-07-18 | |
| NCT04574453 | COMPLETED | Osteoarthritis, Knee |
I.R.A. Istituto Ricerche Applicate S.p.A. |
2020-06-29 | |
| NCT04103918 | COMPLETED | Wrinkle |
I.R.A. Istituto Ricerche Applicate S.p.A. |
2020-08-24 | |
| NCT04377256 | COMPLETED | Bone Resorption; Tooth Loss |
Saint-Joseph University |
2020-05-01 | |
| NCT04486794 | COMPLETED | Tear Trough Eyelid Deformity |
Erevna Innovations Inc. |
2019-07-07 | |
| NCT05072899 | COMPLETED | Chronic Shoulder Pain |
Assiut University |
2019-06-15 | |
| NCT04103125 | COMPLETED | Wrinkle |
I.R.A. Istituto Ricerche Applicate S.p.A. |
2020-07-14 | |
| NCT03743818 | COMPLETED | Osteoarthritis |
Universidad Católica de Ávila |
2020-07-08 | |
| NCT04625179 | COMPLETED | Edentulous; Alveolar Process, Atrophy |
Hams Hamed Abdelrahman |
2019-12-03 | |
| NCT04332445 | COMPLETED | Sensitivity, Contact |
Herbarium Laboratorio Botanico Ltda |
2020-10-26 | |
| NCT02964143 | UNKNOWN | Knee Osteoarthritis |
Regen Lab SA |
2020-06-01 | |
| NCT02708706 | COMPLETED | Adhesive Capsulitis |
Taipei Veterans General Hospital, Taiwan |
2016-03 | |
| NCT06310863 | COMPLETED | Dermal Fillers |
Asan Medical Center |
2019-10-07 | |
| NCT02984228 | COMPLETED | Osteoarthritis; Shoulder Pain |
Hospital for Special Surgery, New York |
2014-12 | PHASE4 |
| NCT03870646 | UNKNOWN | Critical Illness; Tracheostomy Complication; Mechanical Ventilation Complication; Plug; Mucus |
Hospital Universitario Virgen de la Arrixaca |
2019-04-01 | PHASE3 |
| NCT04821804 | COMPLETED | Gingival Recession, Plastic Surgery |
Jordan University of Science and Technology |
2020-01-02 | PHASE2; PHASE3 |
| NCT03240302 | UNKNOWN | Infertility |
Hillel Yaffe Medical Center |
2017-09 | |
| NCT03477630 | COMPLETED | Osteoarthritis |
Karla Andrea Arias Varela |
2019-02-14 | PHASE3 |
| NCT04652817 | COMPLETED | Labia Majora Atrophy and Hypotrophy |
Mesoestetic Pharma Group S.L. |
2019-11-11 | |
| NCT04438434 | UNKNOWN | Impacted Third Molar Tooth; Healing Surgical Wounds |
University of Milan |
2020-06 | PHASE3 |
| NCT04438421 | UNKNOWN | Gingivitis; Bleeding Gum |
University of Milan |
2020-06 | PHASE3 |
| NCT04446533 | UNKNOWN | Periodontitis; Bleeding Gum; Pocket, Periodontal |
University of Milan |
2020-06 | PHASE3 |
| NCT03166865 | UNKNOWN | Osteoarthritis of the Knee |
Liaocheng People's Hospital |
2018-10-01 | PHASE1; PHASE2 |
| NCT02412735 | COMPLETED | Degenerative Disc Disease |
Mesoblast, Ltd. |
2015-03-06 | PHASE3 |
| NCT04798703 | COMPLETED | Bladder Carcinoma in Situ (CIS) |
Fidia Farmaceutici s.p.a. |
2017-05-24 | PHASE1 |
| NCT03461198 | UNKNOWN | Wrinkle |
Goldman, Butterwick, Fitzpatrick and Groff |
2019-02-26 | |
| NCT03668665 | WITHDRAWN | Wound Heal |
RWTH Aachen University |
2018-10 | PHASE3 |
| NCT03077009 | UNKNOWN | Plantaris Friction Syndrome; Non-Insertional Achilles Tendinopathy |
Fortius Clinic |
2017-03-20 | PHASE4 |
| NCT04134611 | COMPLETED | Anterior Knee Pain Syndrome |
Hawler Medical University |
2017-06-01 | |
| NCT03167333 | UNKNOWN | Synovitis of Knee; Osteoarthritis, Knee |
Taipei Veterans General Hospital, Taiwan |
2020-03-01 | |
| NCT03692026 | UNKNOWN | Immediate Dental Implant |
Cairo University |
2018-10 | PHASE4 |
| NCT04265001 | COMPLETED | Recurrent Aphthous Stomatitis |
Cairo University |
2019-11-01 | PHASE3 |
| NCT03761472 | COMPLETED | Knee Osteoarthritis |
Bezmialem Vakif University |
2019-01-01 | |
| NCT03801564 | UNKNOWN | Knee Osteoarthritis |
Antalya Training and Research Hospital |
2019-01-07 | |
| NCT03656484 | COMPLETED | Chronic Periodontitis |
Concordia Dent Srl |
2019-01-15 | PHASE2 |
| NCT04327947 | COMPLETED | Atrophic Vaginitis; Vaginal Disease |
Herbarium Laboratorio Botanico Ltda |
2019-11-06 | |
| NCT01920152 | COMPLETED | Hip Osteoarthritis |
University of Colorado, Denver |
2013-08 | |
| NCT03999372 | COMPLETED | Infertility, Male |
ClinAmygate |
2019-07-05 | PHASE4 |
| NCT04390100 | COMPLETED | Free Gingival Graft |
Ain Shams University |
2019-02-01 | PHASE4 |
| NCT03242707 | UNKNOWN | Osteoarthritis, Knee |
University of Southern California |
2018-07-01 | |
| NCT03742479 | UNKNOWN | Wrinkle |
Goldman, Butterwick, Fitzpatrick and Groff |
2019-02-26 | |
| NCT04070729 | UNKNOWN | CHRONIC PERIODONTITIS |
Institute of Dental Sciences, Bareilly, Uttar Pradesh, India |
2019-08-28 | |
| NCT03114020 | COMPLETED | Emphysema; Alpha 1-Antitrypsin Deficiency |
Gerard Turino |
2017-03-22 | PHASE2 |
| NCT03728244 | UNKNOWN | Graft Pain; Gingival Recession |
Cairo University |
2019-02 | PHASE1; PHASE2 |
| NCT03031054 | COMPLETED | Carpal Tunnel Syndrome |
Tri-Service General Hospital (TSGH) |
2017-03-01 | |
| NCT04319770 | COMPLETED | Intrabony Periodontal Defect |
University of Roma La Sapienza |
2016-09-06 | |
| NCT03408145 | COMPLETED | Osteoarthritis, Knee |
The Stone Research Foundation for Sports Medicine and Arthritis |
2018-01-04 | |
| NCT03938883 | COMPLETED | Ophthalmology; Photorefractive Keratectomy ("PRK"); Laser Assisted Surgery; Refractive Surgery |
Eyegate Pharmaceuticals, Inc. |
2019-06-25 | |
| NCT03463499 | COMPLETED | Interstitial Cystitis |
Samsung Medical Center |
2017-09-22 | |
| NCT04675385 | COMPLETED | Chronic Periodontitis, Hyaluronic Acid |
University of Medicine and Pharmacy at Ho Chi Minh City |
2019-06-21 | PHASE4 |
| NCT05609617 | COMPLETED | Aging |
Laboratoires FILLMED |
2019-06-11 | |
| NCT05210686 | COMPLETED | Periodontal Pocket |
University of Roma La Sapienza |
2018-02-19 | |
| NCT04645576 | COMPLETED | Aging |
Laboratoires FILLMED |
2019-05-14 | |
| NCT04647513 | COMPLETED | Loss of Face Volume |
Laboratoires FILLMED |
2019-04-12 | |
| NCT03814707 | UNKNOWN | Pain, Postoperative |
mostafa soliman |
2019-01-10 | |
| NCT02955381 | TERMINATED | Acne; Acne Scars; AdverseEvent |
Schweiger Dermatology, PLLC |
2017-03-28 | |
| NCT03920553 | COMPLETED | Frenulum; Hypertrophy, Lip |
Gazi University |
2019-01-02 | |
| NCT03381248 | COMPLETED | Osteoarthritis of the Knee |
Avanos Medical |
2017-12-07 | |
| NCT04326985 | COMPLETED | Osteoarthritis, Knee |
Chinese University of Hong Kong |
2015-01-31 | EARLY_PHASE1 |
| NCT02698813 | UNKNOWN | Senescence Wrinkles, Acne, Pitting Scar |
South China Research Center for Stem Cell and Regenerative Medicine |
2016-12 | PHASE1 |
| NCT04345744 | COMPLETED | Periodontal Diseases; Periodontal Pocket |
University of Pisa |
2016-01 | |
| NCT03313934 | UNKNOWN | Tear Trough Hollowing, Under Eye Bags |
Rejuva Medical Aesthetics |
2017-11 | EARLY_PHASE1 |
| NCT03569683 | COMPLETED | Gingival Overgrowth |
Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre |
2018-05-30 | |
| NCT04358120 | COMPLETED | Osteo Arthritis Knee |
Fidia Farmaceutici s.p.a. |
2017-11-28 | |
| NCT02739880 | COMPLETED | Menopause; Dyspareunia |
Centre Hospitalier Universitaire de Nīmes |
2017-06-19 | |
| NCT04525066 | COMPLETED | Head and Neck Neoplasms; Head and Neck Squamous Cell Carcinoma; Voice Disorders; Laryngeal Cancer |
Ayhman Al Afif |
2013-08-13 | PHASE2 |
| NCT04798443 | COMPLETED | Vesico-Ureteral Reflux |
Elsayed Salih |
2015-06-04 | |
| NCT03332602 | COMPLETED | Iron-deficiency |
Swiss Federal Institute of Technology |
2018-04-04 | |
| NCT02930499 | SUSPENDED | Venous Ulcers |
Calvary Hospital, Bronx, NY |
2016-01 | |
| NCT03200288 | COMPLETED | Knee Osteoarthritis |
IBSA Institut Biochimique SA |
2017-06-29 | PHASE3 |
| NCT02694146 | COMPLETED | Coxarthrosis |
Fundación Pública Andaluza Progreso y Salud |
2016-03 | PHASE3 |
| NCT02868749 | COMPLETED | Atrophy |
Vandeputte, Joan, M.D. |
2017-03-22 | |
| NCT02156427 | COMPLETED | Vitiligo; Piebaldism |
Laboratoires Genévrier |
2014-04-29 | PHASE3 |
| NCT03871218 | COMPLETED | Gingival Recession |
Gazi University |
2017-04-01 | PHASE2 |
| NCT06059274 | COMPLETED | Anti-aging |
Cosmetique Active International |
2018-03-14 | |
| NCT03245463 | COMPLETED | Osteoarthritis, Knee |
Hospital for Special Surgery, New York |
2017-08-09 | PHASE4 |
| NCT02640144 | UNKNOWN | Cartilage Damage |
Ziv Medical Center |
2017-02 | PHASE4 |
| NCT03324997 | WITHDRAWN | Wrinkle |
Heidi Waldorf |
2018-01-28 | PHASE2 |
| NCT02693808 | COMPLETED | Thyroid-Associated Ophthalmopathy |
Haukeland University Hospital |
2015-11 | |
| NCT02966925 | COMPLETED | Vulvar Atrophy |
Regen Lab SA |
2016-03 | |
| NCT02613247 | UNKNOWN | Patellofemoral Pain Syndrome |
University of Calgary |
2016-03 | PHASE2 |
| NCT03825133 | COMPLETED | Knee Osteoarthritis |
Clinical Center of Vojvodina |
2016-04-01 | PHASE4 |
| NCT03180125 | COMPLETED | Carpal Tunnel Syndrome |
Assiut University |
2017-08-15 | PHASE1 |
| NCT03311906 | COMPLETED | Periodontitis |
Riyadh Colleges of Dentistry and Pharmacy |
2017-02-15 | PHASE4 |
| NCT02679924 | UNKNOWN | Problem of Aging |
Isabella Guiha |
2015-11 | |
| NCT02465853 | COMPLETED | Shoulder Pain; Stroke; Rotator Cuff Injuries |
Chang Gung Memorial Hospital |
2015-01 | |
| NCT02949466 | UNKNOWN | Physical Activity; Functional Performance |
Taipei Medical University |
2016-10 | PHASE4 |
| NCT03131882 | UNKNOWN | Trigger Digit |
Mahidol University |
2016-10-01 | PHASE2; PHASE3 |
| NCT03807596 | COMPLETED | Chronic Periodontitis |
Cairo University |
2017-03-16 | |
| NCT02165917 | UNKNOWN | Endometriosis |
Pius-Hospital Oldenburg |
2015-05 | PHASE4 |
| NCT03274232 | COMPLETED | Face Skin Photoaging |
Derming SRL |
2016-10-27 | |
| NCT03204565 | COMPLETED | Gingival Recession |
University of Roma La Sapienza |
2015-09 | |
| NCT05456971 | COMPLETED | Aging |
Laboratoires FILLMED |
2016-09-12 | |
| NCT01811654 | COMPLETED | Patellofemoral Pain Syndrome |
NYU Langone Health |
2013-04 | |
| NCT01813565 | TERMINATED | Interstitial Cystitis |
Asan Medical Center |
2013-03-20 | |
| NCT01895959 | COMPLETED | Knee Osteoarthritis |
University of California, San Francisco |
2013-08 | PHASE4 |
| NCT02702206 | COMPLETED | Shoulder Pain; Subdeltoid Bursitis; Subacromial Bursitis |
Shin Kong Wu Ho-Su Memorial Hospital |
2014-08 | |
| NCT02391974 | UNKNOWN | Chronic Periodontitis |
Teoxane SA |
2015-02 | PHASE4 |
| NCT03074344 | COMPLETED | Dry Eye Syndrome |
Azienda Ospedaliera Universitaria Policlinico "G. Martino" |
2016-05 | |
| NCT02625727 | UNKNOWN | Physical Activity |
Taipei Medical University |
2015-08 | PHASE4 |
| NCT02629380 | COMPLETED | Meniscus Lesion |
Istituto Ortopedico Rizzoli |
2012-12 | PHASE4 |
| NCT01697423 | COMPLETED | the Treatment of Knee Osteoarthritis |
Assistance Publique Hopitaux De Marseille |
2012-12-11 | PHASE2 |
| NCT01787630 | UNKNOWN | Prostatic Cancer |
Anders Widmark |
2010-01 | PHASE2; PHASE3 |
| NCT02559908 | COMPLETED | Chin Retrusion |
Allergan |
2015-02-26 | |
| NCT02654522 | COMPLETED | Dermal Filler |
Steve Yoelin M.D. Medical Associates, Inc. |
2016-01 | PHASE1 |
| NCT02170857 | COMPLETED | Chronic Periodontitis With Infra-bony Defects |
Damascus University |
2014-06 | |
| NCT01935531 | COMPLETED | Actinic Keratoses |
University Hospital Regensburg |
2013-06 | PHASE4 |
| NCT02368561 | UNKNOWN | Insertional Achilles Tendinitis |
Meir Medical Center |
2015-03 | EARLY_PHASE1 |
| NCT02877069 | COMPLETED | Skin Roughness |
Allergan |
2015-09 | PHASE4 |
| NCT03636971 | COMPLETED | Gait; Knee Osteoarthritis; Injection |
Brigitte Jolles, MD |
2013-05-01 | PHASE2; PHASE3 |
| NCT02832583 | COMPLETED | Skin Wrinkling |
Regen Lab SA |
2014-12 | |
| NCT01524913 | COMPLETED | Temporomandibular Joint Dysfunction; Pain; Arthrocentesis |
Emory University |
2012-01 | PHASE4 |
| NCT02369380 | COMPLETED | Metatarsalgia |
Galderma R&D |
2014-11 | |
| NCT02876276 | COMPLETED | Interdental Papillary Reconstruction |
Krishnadevaraya College of Dental Sciences & Hospital |
2012-11 | PHASE4 |
| NCT02330822 | COMPLETED | Patients With Dental Extraction |
Damascus University |
2014-12 | |
| NCT02127723 | COMPLETED | Cellulite of the Buttocks |
Galderma R&D |
2014-04 | |
| NCT02686047 | COMPLETED | Knee Osteoarthritis |
Kaohsiung Veterans General Hospital. |
2014-09 | PHASE2; PHASE3 |
| NCT02709525 | COMPLETED | Alveolar Bone Loss |
Federal University of Minas Gerais |
2012-07 | PHASE1; PHASE2 |
| NCT03329235 | COMPLETED | Osteoarthritis, Knee |
Cangzhou Central Hospital |
2015-01-01 | EARLY_PHASE1 |
| NCT02253147 | COMPLETED | Nasolabial Folds, Wrinkles |
Teoxane SA |
2014-09 | |
| NCT02588872 | COMPLETED | Osteoarthritis, Knee |
Rush University Medical Center |
2011-08 | |
| NCT05822778 | COMPLETED | Dermal Filler |
Maxigen Biotech Inc. |
2014-02-13 | |
| NCT02039804 | UNKNOWN | Osteoarthritis |
Universitaire Ziekenhuizen KU Leuven |
2014-03 | PHASE3 |
| NCT02951585 | COMPLETED | Knee Osteoarthritis |
Laboratoires Vivacy |
2013-05 | |
| NCT04212741 | COMPLETED | Knee Osteoarthritis |
China Medical University Hospital |
2012-11 | |
| NCT02448407 | COMPLETED | Knee Osteoarthritis |
Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud |
2014-01 | PHASE3 |
| NCT01950793 | COMPLETED | Trigger Finger |
Taipei Veterans General Hospital, Taiwan |
2012-11 | |
| NCT01891396 | COMPLETED | Knee Osteoarthritis |
Anika Therapeutics, Inc. |
2013-06 | |
| NCT01256788 | TERMINATED | Meniscus Tear; Chondropathy/Degenerative Joint Disease (DJD) |
The Hawkins Foundation |
2010-09 | |
| NCT02063971 | UNKNOWN | Skin Aging |
Adele Sparavigna |
2013-12 | |
| NCT01680497 | COMPLETED | Moderate to Severe Nasolabial Folds |
Allergan |
2012-06-01 | |
| NCT01545557 | COMPLETED | Volume Loss (Soft Tissue Ptosis or Atrophy ) |
Galderma R&D |
2012-02-21 | |
| NCT02091674 | COMPLETED | Ankle Sprain |
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's |
2013-08 | PHASE2 |
| NCT01459640 | UNKNOWN | Osteoarthritis |
National University of Malaysia |
2011-03 | PHASE2 |
| NCT00958425 | WITHDRAWN | Cicatrix |
Nova Scotia Health Authority |
2014-01-01 | PHASE3 |
| NCT02958761 | COMPLETED | Knee Osteoarthrosis |
Fondazione IRCCS Policlinico San Matteo di Pavia |
2010-08 | PHASE2 |
| NCT04833738 | COMPLETED | Subacromial Impingement; Pain, Shoulder |
Şeyhmus KAPLAN |
2013-09-11 | |
| NCT01586312 | COMPLETED | Osteoarthritis, Knee; Arthritis of Knee; Knee Osteoarthritis |
Red de Terapia Celular |
2012-04 | PHASE1; PHASE2 |
| NCT01846039 | COMPLETED | Asian Nose Enhancement |
Allergan |
2013-04-01 | |
| NCT01670578 | COMPLETED | Knee Chondropathy; Osteoarthritis, Knee |
Istituto Ortopedico Rizzoli |
2009-02 | PHASE4 |
| NCT02337166 | COMPLETED | Periodontitis |
Universidade Federal Fluminense |
2002-12 | PHASE1; PHASE2 |
| NCT01290367 | COMPLETED | Degenerative Disc Disease |
Mesoblast, Ltd. |
2011-08 | PHASE2 |
| NCT01874574 | COMPLETED | Knee Osteoarthritis |
Thammasat University |
2011-01 | PHASE4 |
| NCT01948583 | COMPLETED | Vaginal Dryness; Menopause |
Derming SRL |
2013-05 | PHASE4 |
| NCT01997203 | TERMINATED | Chronic Hepatitis C |
Dr. Nadia AbdelAaty AbdelKader |
2012-04 | PHASE3 |
| NCT02014428 | COMPLETED | Atrophic Vaginitis |
AGUNCO Obstetrics and Gynecology Centre |
PHASE4 | |
| NCT00993707 | COMPLETED | Chronic Obstructive Pulmonary Disease (COPD) |
Turino, Gerard, M.D. |
2010-11 | PHASE2 |
| NCT02039531 | COMPLETED | Knee Osteoarthritis |
Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias |
2011-08 | PHASE3 |
| NCT01557868 | COMPLETED | Osteoarthritis, Knee |
American Orthopaedic Society for Sports Medicine |
2008-10 | PHASE4 |
| NCT01270412 | UNKNOWN | Osteoarthritis of the Knee |
Meir Medical Center |
2011-09 | PHASE2; PHASE3 |
| NCT02207608 | COMPLETED | Poisoning by BCG Vaccine |
University of Rome Tor Vergata |
2011-09 | PHASE2 |
| NCT01079455 | UNKNOWN | Coxarthrosis |
University Hospital Pellenberg |
2010-05 | PHASE3 |
| NCT01829451 | COMPLETED | Menorrhagia |
University of Oulu |
2011-01 | |
| NCT02220621 | COMPLETED | Intrauterine Adhesion |
Xiaozheng Shu |
2011-10 | |
| NCT01290497 | COMPLETED | Osteoarthritis of the Knee |
Tedec-Meiji Farma, S.A. |
2010-11 | PHASE4 |
| NCT00931268 | COMPLETED | Atrophy |
Galderma R&D |
2009-08 | |
| NCT01186835 | COMPLETED | Forehead/Glabellar Rhytid Complexes |
Northwestern University |
2011-02 | |
| NCT01305187 | COMPLETED | Physiological Stress; Disorder of Aging; Skin Diseases; Wrinkles; Nasolabial Folds |
Merz Pharmaceuticals GmbH |
2011-02 | PHASE4 |
| NCT01029535 | COMPLETED | Mid-face Volume Deficiency |
Allergan |
2009-01 | |
| NCT01151436 | COMPLETED | Facial Wrinkles |
Galderma R&D |
2010-03 | |
| NCT01387620 | COMPLETED | Corneal Edema; Intraocular Pressure |
University of Sao Paulo |
2009-06 | PHASE4 |
| NCT01066026 | COMPLETED | Wrinkles |
Hexsel Dermatology Clinic |
2009-07 | PHASE2 |
| NCT00890487 | UNKNOWN | Vaginal Disease |
University of Messina |
2009-05 | |
| NCT00556608 | COMPLETED | Osteoarthritis, Knee |
IBSA Institut Biochimique SA |
2007-11 | PHASE4 |
| NCT00778076 | UNKNOWN | Osteoarthritis, Knee |
University of Western Ontario, Canada |
2008-07 | PHASE4 |
| NCT00728611 | COMPLETED | Osteoarthritis of the Knee |
Meir Medical Center |
2008-01 | PHASE2; PHASE3 |
| NCT06196021 | COMPLETED | Knee Osteoarthritis |
Balikesir University |
2006-03-01 | |
| NCT00731289 | COMPLETED | Osteoarthritis |
Philipps University Marburg |
2003-07 | PHASE4 |
| NCT01546012 | WITHDRAWN | Assess the Patient Feeling About the Handiness of Two Different Vials Used to Deliver Both, Unpreserved Hyaluronic Eye Drops |
Laboratoires Thea |
||
| NCT00782197 | COMPLETED | Joint Disease |
Biotechnology Institute IMASD |
2008-01 | PHASE4 |
| NCT01442571 | UNKNOWN | Cartilage Injury |
Hadassah Medical Organization |
PHASE1; PHASE2 | |
| NCT00429520 | COMPLETED | Nasolabial Folds |
Merz Pharmaceuticals GmbH |
2005-12 | PHASE4 |
(data from https://clinicaltrials.gov, updated on 2026-05-15)
Check the
Hyaluronic acid (Hyaluronan)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.