CAS No. 51-56-9
Chemical Information
| CAS Number | 51-56-9 | |
|---|---|---|
| Molecular Formula |
C16H21NO3.HBr |
|
| Molecular Weight (MW) | 356.25 | |
| SMILES | CN1C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O.Br |
Biological Activity
Homatropine bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that potently inhibits endothelial and vascular smooth muscle muscarinic receptors. By blocking cholinergic activation of muscarinic receptors, it suppresses downstream G-protein-mediated signal transduction, inhibiting intracellular calcium mobilization and smooth muscle contraction. This competitive receptor inhibition effectively attenuates parasympathetic neurotransmission and regulates cholinergic signaling across diverse cardiovascular and peripheral tissue models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 71 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.