CAS No. 51-74-1

Batch: Purity:99.99
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Histamine Phosphate Chemical Structure
Chemical Structure
Check the Histamine Phosphate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 51-74-1
Molecular Formula

C5H9N.2H3O4P
Molecular Weight (MW) 307.14
SMILES C1=C(NC=N1)CCN.OP(=O)(O)O.OP(=O)(O)O

Biological Activity

Histamine is an endogenous biogenic amine that acts as an agonist at histamine H1 and H2 receptors to regulate vascular tone and gastric function. It acts directly on blood vessels to dilate arteries and capillaries mediated by both H1- and H2-receptors, promoting vasodilation and altering hemodynamics. Additionally, histamine phosphate is used to establish animal models of gastric and intestinal ulcers for experimental studies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 61 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Hill SJ, et al. Pharmacol Rev. 1997;49(3):253-78.

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Note: Technical data last updated: Sep 1, 2026.