CAS No. 55-97-0

Batch: Purity:100.00
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Hexamethonium Dibromide Chemical Structure
Chemical Structure
Check the Hexamethonium Dibromide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 55-97-0
Molecular Formula

C12H30N2.2Br
Molecular Weight (MW) 362.19
SMILES C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

Ordering Information

Biological Activity

Hexamethonium Dibromide is a selective antagonist of neuronal-type nicotinic acetylcholine receptors (nAChR) located in autonomic ganglia. By blocking channel opening and synaptic transmission in ganglionic neurons, it impairs both sympathetic and parasympathetic autonomic signaling pathways. This inhibition suppresses downstream neurotransmitter release and modulates ganglionic phenotypes associated with autonomic nervous system function.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 73 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.