CAS No. 343-27-1

Batch: Purity:99.81
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Harmine Hydrochloride (Telepathine) Chemical Structure
Chemical Structure
Check the Harmine Hydrochloride (Telepathine) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 343-27-1
Molecular Formula

C13H12N2O.HCl
Molecular Weight (MW) 248.71

Ordering Information

Biological Activity

Harmine Hydrochloride is a cell-permeable beta-carboline alkaloid that acts as a competitive inhibitor of ATP binding to DYRK1A, demonstrating selectivity over DYRK2, alongside inhibition of cdc-like kinases (CLKs), monoamine oxidases, PPARγ, and 5-HT2A serotonin receptors. Selective inhibition of DYRK1A attenuates tau phosphorylation and regulates NFAT-mediated transcriptional signaling, suppressing downstream cellular proliferation and modulating neurochemical signaling pathways.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

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Note: Technical data last updated: Sep 1, 2026.