CAS No. 66852-54-8

Batch: Purity:99.92
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Halobetasol Propionate Chemical Structure
Chemical Structure
Check the Halobetasol Propionate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(6S,8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
CAS Number 66852-54-8
Molecular Formula

C25H31ClF2O5
Molecular Weight (MW) 484.96
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)CCl
InChIKey BDSYKGHYMJNPAB-LICBFIPMSA-N

Ordering Information

Biological Activity

Halobetasol Propionate is a high-potency synthetic corticosteroid that acts as a glucocorticoid receptor agonist. Upon binding, it suppresses inflammatory signal transduction pathways, leading to the inhibition of pro-inflammatory cytokine release and reduced capillary permeability. These cellular actions effectively attenuate immune cell infiltration and cutaneous inflammation, making it an effective dermatologic agent for treating conditions such as plaque psoriasis.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 97 mg/mL (200.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 38 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.