CAS No. 660868-91-7
Batch:
Purity:99.96
Chemical Structure
Check the
GW843682X
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide | |
|---|---|---|
| CAS Number | 660868-91-7 | |
| Molecular Formula |
C22H18F3N3O4S |
|
| Molecular Weight (MW) | 477.46 | |
| SMILES | COC1=C(OC)C=C2[N](C=NC2=C1)C3=CC(=C(S3)C(N)=O)OCC4=C(C=CC=C4)C(F)(F)F | |
| InChIKey | JSKUWFIZUALZLX-UHFFFAOYSA-N |
Biological Activity
GW843682X is a selective, ATP-competitive inhibitor of PLK1 and PLK3, exhibiting over 100-fold selectivity against a panel of ~30 other protein kinases. By inhibiting polo-like kinase activity, this compound disrupts mitotic progression, leading to spindle abnormalities, G2/M phase cell cycle arrest, and eventual apoptosis in various human cancer cell lines. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.