CAS No. 504433-23-2
Batch:
Purity:99.53
Chemical Structure
Check the
GW441756
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one | |
|---|---|---|
| CAS Number | 504433-23-2 | |
| Molecular Formula |
C17H13N3O |
|
| Molecular Weight (MW) | 275.3 | |
| SMILES | CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O | |
| InChIKey | NXNQLECPAXXYTR-LCYFTJDESA-N |
GW441756 is a potent and selective inhibitor of TrkA kinase (IC50 2 nM) with minimal inhibitory activity against c-Raf1 and CDK2. By selectively inhibiting cellular TrkA-mediated signaling pathways, GW441756 suppresses downstream neurotrophin signaling and promotes a marked increase in caspase-3 expression, ultimately triggering apoptotic cell death in target cancer cell lines. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
27.5 mg/mL
(99.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
25 mg/mL
(90.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.