CAS No. 29110-48-3

Batch: Purity:99.98
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Guanfacine Hydrochloride Chemical Structure
Chemical Structure
Check the Guanfacine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 29110-48-3
Molecular Formula

C9H9Cl2N3O.HCl
Molecular Weight (MW) 282.55
SMILES C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl

Ordering Information

Biological Activity

Guanfacine Hydrochloride is a selective agonist targeting the α2A-adrenergic receptor. Ligand engagement promotes coupling to inhibitory G proteins (Gi/o), thereby suppressing adenylate cyclase activity and decreasing intracellular cyclic AMP (cAMP) levels. Downstream, this signal transduction cascade reduces protein kinase A signaling and modulates membrane ion channel conductances, ultimately attenuating sympathetic neurotransmitter release and lowering vascular tone.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 56 mg/mL (198.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 56 mg/mL
Water 30 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.