CAS No. 23256-50-0
| CAS Number | 23256-50-0 | |
|---|---|---|
| Molecular Formula |
C8H8Cl2N4.C2H4O2 |
|
| Molecular Weight (MW) | 291.13 | |
| SMILES | CC(=O)O.C1=CC(=C(C(=C1)Cl)C=NN=C(N)N)Cl |
Guanabenz Acetate is a selective agonist of α2A-, α2B-, and α2C-adrenergic receptors, as well as an inhibitor of the PPP1R15A/GADD34 regulatory subunit of protein phosphatase 1. By targeting PPP1R15A/GADD34, it selectively attenuates dephosphorylation of eukaryotic translation initiation factor 2 subunit alpha (eIF2α) under stress conditions. This inhibition modulates the integrated stress response pathway, enhancing cellular resistance to protein misfolding and proteotoxic stress. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(51.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
58 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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