CAS No. 90-05-1
Batch:
Purity:98
Chemical Structure
Check the
Guaiacol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methoxyphenol | |
|---|---|---|
| CAS Number | 90-05-1 | |
| Molecular Formula |
C7H8O2 |
|
| Molecular Weight (MW) | 124.14 | |
| InChIKey | LHGVFZTZFXWLCP-UHFFFAOYSA-N |
Guaiacol is a natural phenolic compound that exerts anti-inflammatory activity through the inhibition of key inflammatory cascades. It suppresses lipopolysaccharide-stimulated cyclooxygenase-2 (COX-2) expression and blocks nuclear factor-kappa B (NF-κB) activation in macrophage cells. By downregulating COX-2 levels and blocking NF-κB pathway signaling, guaiacol diminishes downstream pro-inflammatory mediator production and mitigates cellular inflammatory responses.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
24 mg/mL
(193.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.