CAS No. 1216744-19-2
Batch:
Purity:99.66
Chemical Structure
Check the
GSK4112
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | tert-butyl 2-[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]acetate | |
|---|---|---|
| CAS Number | 1216744-19-2 | |
| Molecular Formula |
C18H21ClN2O4S |
|
| Molecular Weight (MW) | 396.89 | |
| SMILES | CC(C)(C)OC(=O)CN(CC1=CC=C(C=C1)Cl)CC2=CC=C(S2)[N+](=O)[O-] | |
| InChIKey | WYSLOKHVFKLWOU-UHFFFAOYSA-N |
GSK4112 is a functional nuclear receptor Rev-erbα agonist with an EC50 of 0.4 μM. Upon binding to Rev-erbα, GSK4112 recruits co-repressors to modulate circadian clock-regulated gene networks and repress the transcription of key gluconeogenic genes in liver cells. This downstream transcriptional repression subsequently reduces hepatic glucose output in primary hepatocytes, linking nuclear receptor activity to metabolic gene regulation.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(171.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.