CAS No. 1346704-33-3

Batch: Purity:99.95
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GSK343 Chemical Structure
Chemical Structure
Check the GSK343 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)-4-pyridinyl]-1-propan-2-ylindazole-4-carboxamide
CAS Number 1346704-33-3
Molecular Formula

C31H39N7O2
Molecular Weight (MW) 541.69
SMILES CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
InChIKey ULNXAWLQFZMIHX-UHFFFAOYSA-N

Ordering Information

Biological Activity

GSK343 is a potent, selective histone methyltransferase EZH2 inhibitor with 60-fold selectivity over EZH1 and greater than 1000-fold selectivity over other histone methyltransferases. By targeting the catalytic subunit of the PRC2 complex, it inhibits trimethylation of lysine 27 on histone H3 (H3K27me3) to regulate gene expression, decrease cell proliferation, and induce autophagy in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Ethanol 4 mg/mL
DMSO 1 mg/mL (1.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.