CAS No. 1018673-42-1
Batch:
Purity:99.97
Chemical Structure
Check the
GSK3117391
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | cyclopentyl (2S)-2-cyclohexyl-2-[[6-[3-(hydroxyamino)-3-oxopropyl]-3-pyridinyl]methylamino]acetate | |
|---|---|---|
| CAS Number | 1018673-42-1 | |
| Molecular Formula |
C22H33N3O4 |
|
| Molecular Weight (MW) | 403.52 | |
| SMILES | ONC(=O)CCC1=NC=C(CNC(C2CCCCC2)C(=O)OC3CCCC3)C=C1 | |
| InChIKey | AFDPFLDWOXXHQM-NRFANRHFSA-N |
Biological Activity
GSK3117391 is a potent histone deacetylase inhibitor that targets histone deacetylase enzymes to regulate epigenetic modification. By suppressing histone deacetylase activity, the compound promotes histone hyperacetylation and relaxes chromatin structure, leading to altered gene expression. This modulation regulates cellular processes including cell cycle arrest, differentiation, and induction of apoptosis in various cellular models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(200.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.