CAS No. 1902123-72-1

Batch: Purity:99.93
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GSK2879552 Dihydrochloride Chemical Structure
Chemical Structure
Check the GSK2879552 Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]piperidin-1-yl]methyl]benzoic acid;dihydrochloride
CAS Number 1902123-72-1
Molecular Formula

C23H28N2O2.2HCl
Molecular Weight (MW) 437.4
SMILES C1CN(CCC1CNC2CC2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O.Cl.Cl
InChIKey QEKGSBZKRLHQSZ-VSIGASKDSA-N

Ordering Information

Biological Activity

GSK2879552 Dihydrochloride is an orally bioavailable, selective, irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A). LSD1 functions as a histone demethylase that regulates gene expression by targeting methylated histones within chromatin complexes. Targeted inhibition of LSD1 modulates transcriptional repression pathways, leading to altered histone methylation, reactivation of silenced genes, and suppression of cell proliferation in sensitive cancer models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 44 mg/mL
DMSO 29 mg/mL (66.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.