CAS No. 1404456-53-6

Batch: Purity:99.68
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GSK2830371 Chemical Structure
Chemical Structure
Check the GSK2830371 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[[(5-chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl]thiophene-2-carboxamide
CAS Number 1404456-53-6
Molecular Formula

C23H29ClN4O2S
Molecular Weight (MW) 461.02
SMILES CC1=C(C=C(C=N1)Cl)NCC2=CC=C(S2)C(=O)NC(CC3CCCC3)C(=O)NC4CC4
InChIKey IVDUVEGCMXCMSO-FQEVSTJZSA-N

Ordering Information

Biological Activity

GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with an IC50 of. By selectively inhibiting Wip1, GSK2830371 blocks the dephosphorylation of key DNA damage response proteins, thereby reactivating the p53 signaling pathway. This downstream activation enhances p53 phosphorylation, induces p21 expression, and leads to cell cycle arrest and reduced cell proliferation in cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (199.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 92 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.