CAS No. 1337532-29-2
Batch:
Purity:99.98
Chemical Structure
Check the
GSK2656157
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone | |
|---|---|---|
| CAS Number | 1337532-29-2 | |
| Molecular Formula |
C23H21FN6O |
|
| Molecular Weight (MW) | 416.45 | |
| SMILES | CC1=NC(=CC=C1)CC(=O)N2CCC3=C2C=CC(=C3F)C4=CN(C5=NC=NC(=C45)N)C | |
| InChIKey | PRWSIEBRGXYXAJ-UHFFFAOYSA-N |
GSK2656157 is an ATP-competitive, highly selective inhibitor of PERK (IC50 0.9 nM). By directly targeting PERK, it effectively blocks PERK autophosphorylation and attenuates downstream eIF2α phosphorylation within the unfolded protein response pathway. This signaling inhibition leads to decreased apoptosis, suppresses excessive autophagy, and impairs downstream phenotypes including tumor proliferation and angiogenesis in preclinical cancer models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10.3 mg/mL
(24.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| Ethanol | 20 mg/mL |
| DMSO |
15.5 mg/mL
(37.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
83 mg/mL
(199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
20 mg/mL
(48.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
10.38 mg/mL
(24.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- GSK2656157 Mechanism of Action: PERK Inhibition in Tumor Cell Research
- GSK2656157 Working Concentration | Cell Culture | Treatment
- GSK2656157 Solubility in DMSO
- GSK2656157 Stock Solution
- GSK2656157 Storage
- GSK2656157 Stability
- GSK2656157 Combination Database
- GSK2656157 Molecular Weight
- GSK2656157 SMILES
- GSK2656157 Chemical Structure (2D and 3D)
- GSK2656157 Cayman (17372)? Try a better option.
- GSK2656157 Sigma (516535)? Try a better option.
- GSK2656157 Abcam (ab273622)? Try a better option.
- GSK2656157 MedChemExpress (HY-13820)? Try a better option.
- GSK2656157 APExBIO (B2175)? Try a better option.
- GSK2656157 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.