GSK2606414: Selectivity & Specificity
GSK2606414 is a potent inhibitor of PERK, GCN2, RIPK1 (< 1000 nM), c-kit (< 1000 nM), AuroraBkinase (< 1000 nM), BRK (< 1000 nM), MAP3K10 (< 1000 nM), c-MER (< 1000 nM), DDR2 (< 1000 nM), MYLK2 (< 1000 nM), IKBKE (1000 nM), TRKC (1000 nM), MAP3K11 (1000 nM), RET (1000 nM), LCK (1000 nM), NEK4 (1000 nM), MAP4K5 (1000 nM), MAP3K9 (1000 nM), TRKA (1000 nM), AXL (1000 nM), TRKB (1000 nM), YES1 (1000 nM), WNK2 (1000 nM). GSK2606414 exhibits the greatest inhibitory potency toward PERK.