CAS No. 1337531-36-8
Batch:
Purity:99.85
Chemical Structure
Check the
GSK2606414
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone | |
|---|---|---|
| CAS Number | 1337531-36-8 | |
| Molecular Formula |
C24H20F3N5O |
|
| Molecular Weight (MW) | 451.44 | |
| SMILES | CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F | |
| InChIKey | SIXVRXARNAVBTC-UHFFFAOYSA-N |
Biological Activity
GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of, exhibiting over 100-fold selectivity against other EIF2AK family enzymes. By inhibiting PERK, it blocks downstream eIF2α phosphorylation, suppressing the unfolded protein response pathway. In cellular and in vivo models, this compound modulates ER stress-induced apoptosis, impairs autophagy, and protects against neurodegeneration. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(199.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 19 mg/mL |
| Water | Insoluble |
| DMSO |
200 mg/mL
(443.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 21 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- GSK2606414 Mechanism of Action: PERK Inhibition in Neuronal Cells Research
- GSK2606414 Working Concentration | Cell Culture | Treatment
- GSK2606414 Solubility in DMSO
- GSK2606414 Stock Solution
- GSK2606414 Storage
- GSK2606414 Stability
- GSK2606414 Combination Database
- GSK2606414 Molecular Weight
- GSK2606414 SMILES
- GSK2606414 Chemical Structure (2D and 3D)
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- GSK2606414 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.