CAS No. 2102933-95-7
Batch:
Purity:99.78
Chemical Structure
Check the
GSK-LSD1 2HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[(1R,2S)-2-phenylcyclopropyl]piperidin-4-amine;dihydrochloride | |
|---|---|---|
| CAS Number | 2102933-95-7 | |
| Molecular Formula |
C14H22Cl2N2 |
|
| Molecular Weight (MW) | 289.24 | |
| SMILES | C1CNCCC1NC2CC2C3=CC=CC=C3.Cl.Cl | |
| InChIKey | PJFZOGMSPBHPNS-WICJZZOFSA-N |
Biological Activity
GSK-LSD1 2HCl is an irreversible, selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of, displaying >1000-fold selectivity over LSD2, MAO-A, and MAO-B. Inhibition of LSD1 blocks demethylation of histone H3 lysine 4 (H3K4), leading to altered gene expression. This blockade suppresses cell proliferation and promotes differentiation in acute myeloid leukemia and small cell lung cancer models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(197.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 57 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.