CAS No. 1191237-69-0

Batch: Purity:99.88
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GS-441524 Chemical Structure
Chemical Structure
Check the GS-441524 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
CAS Number 1191237-69-0
Molecular Formula

C12H13N5O4
Molecular Weight (MW) 291.26
SMILES C1=C2C(=NC=NN2C(=C1)C3(C(C(C(O3)CO)O)O)C#N)N
InChIKey BRDWIEOJOWJCLU-LTGWCKQJSA-N

Ordering Information

Biological Activity

GS-441524 is a potent nucleoside analog inhibitor of feline infectious peritonitis virus (FIPV) with an EC50 of. As a molecular precursor to a pharmacologically active nucleoside triphosphate, it targets viral RNA-dependent RNA polymerase to interrupt viral RNA synthesis. This inhibition suppresses viral replication in host cells, effectively blocking cytopathic effects and downstream viral infection phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 58 mg/mL (199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.