CAS No. 1642839-27-7
Batch:
Purity:99.95
Chemical Structure
Check the
GRK5-IN-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(furan-2-yl)-1-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[4,5-c]pyridin-6-amine | |
|---|---|---|
| CAS Number | 1642839-27-7 | |
| Molecular Formula |
C20H20N4O4 |
|
| Molecular Weight (MW) | 380.4 | |
| SMILES | COC1=C(OC)C(=CC(=C1)NC2=NC=C3N=C([N](C)C3=C2)C4=CC=CO4)OC | |
| InChIKey | CRUXKUKVTMZKSO-UHFFFAOYSA-N |
GRK5-IN-2 is a potent inhibitor of G-protein-coupled receptor kinase 5 (GRK5). Pharmacological inhibition of GRK5 by GRK5-IN-2 modulates hepatic lipid metabolism by reducing hepatic triglyceride accumulation and de novo lipogenesis. These metabolic effects are mediated by decreasing expression of the lipogenic gene Acc2 and upregulating the lipid utilization proteins COXIV and ACSL1 in mouse liver tissue. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.