CAS No. 2922824-09-5
Batch:
Purity:99.95
Chemical Structure
Check the
GPX4-IN-5
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-chloro-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)acetamide | |
|---|---|---|
| CAS Number | 2922824-09-5 | |
| Molecular Formula | C18H17ClFNO5 | |
| Molecular Weight (MW) | 381.78 | |
| SMILES | COC1=CC(N(C2=CC3=C(OCCO3)C=C2)C(CCl)=O)=CC(OC)=C1F | |
| InChIKey | HKXSBJJCHBFTMB-UHFFFAOYSA-N |
Biological Activity
GPX4-IN-5 is a covalent inhibitor targeting glutathione peroxidase 4 (GPX4). Inhibition of GPX4 disrupts intracellular antioxidant defenses and leads to lethal accumulation of lipid peroxides, thereby inducing ferroptotic cell death and suppressing tumor cell proliferation. Consequently, this small molecule serves as an effective research tool for investigating ferroptosis pathways and potential anti-tumor strategies in triple-negative breast cancer. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
76 mg/mL
(199.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.