CAS No. 1139889-93-2
Batch:
Purity:99.35
Chemical Structure
Check the
Golgicide A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3aR,9bS)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline | |
|---|---|---|
| CAS Number | 1139889-93-2 | |
| Molecular Formula |
C17H14F2N2 |
|
| Molecular Weight (MW) | 284.3 | |
| SMILES | C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4 | |
| InChIKey | NJZHEQOUHLZCOX-FTLRAWMYSA-N |
Golgicide A is a potent and rapidly reversible inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1). By blocking GBF1-mediated guanine nucleotide exchange on Arf GTPases, it disrupts COPI coatomer recruitment to Golgi membranes. This inhibition results in the complete and reversible disassembly of the Golgi apparatus, halting vesicle-mediated protein transport and cellular secretion along the secretory pathway.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(200.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.