SMILES:

CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=C[NH]C4=C3C=CC=C4)C5=CC(=CN=C5)C
GNF351 Chemical Structure
Chemical Structure
Check the GNF351 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-(1H-indol-3-yl)ethyl]-2-(5-methyl-3-pyridinyl)-9-propan-2-ylpurin-6-amine
CAS Number 1227634-69-6
Molecular Formula

C24H25N7
Molecular Weight (MW) 411.50
SMILES CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=C[NH]C4=C3C=CC=C4)C5=CC(=CN=C5)C
InChIKey ABXIUYMKZDZUDC-UHFFFAOYSA-N

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (72.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.