CAS No. 1227634-69-6
Batch:
Purity:99.81
Chemical Structure
Check the
GNF351
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-(1H-indol-3-yl)ethyl]-2-(5-methyl-3-pyridinyl)-9-propan-2-ylpurin-6-amine | |
|---|---|---|
| CAS Number | 1227634-69-6 | |
| Molecular Formula |
C24H25N7 |
|
| Molecular Weight (MW) | 411.50 | |
| SMILES | CC(C)[N]1C=NC2=C1N=C(N=C2NCCC3=C[NH]C4=C3C=CC=C4)C5=CC(=CN=C5)C | |
| InChIKey | ABXIUYMKZDZUDC-UHFFFAOYSA-N |
GNF351 is a potent antagonist of the aryl hydrocarbon receptor (AHR) that competes for binding to the AHR ligand-binding pocket with an IC50 of 62 nM. By blocking AHR activation, GNF351 inhibits AHR nuclear translocation, DNA binding, and the transcriptional expression of downstream target genes such as CYP1A1. Consequently, this inhibition suppresses ligand-induced AHR signaling pathways involved in xenobiotic metabolism, cellular differentiation, and immune response regulation.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(72.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.