CAS No. 70-18-8

Batch: Purity:99.97
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GSH (L-Glutathione reduced) Chemical Structure
Chemical Structure
Check the GSH (L-Glutathione reduced) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 70-18-8
Molecular Formula

C10H17N3O6S
Molecular Weight (MW) 307.32
SMILES C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

Ordering Information

Biological Activity

GSH (L-Glutathione reduced) is an endogenous antioxidant, free radical scavenger, and essential detoxifying tripeptide composed of glutamate, cysteine, and glycine. It maintains cellular redox homeostasis by directly neutralizing reactive oxygen species and serving as a substrate for glutathione peroxidase and glutathione S-transferases. Through these redox-dependent signaling mechanisms, GSH prevents oxidative stress-induced cellular damage and supports mitochondrial function and cell survival across mammalian tissues. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 61 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.