Home Biosimilar Antibodies Others Others Glembatumumab (Anti-GPNMB)
For research use only. Not for use in humans.

Glembatumumab (Anti-GPNMB)

Synonyms: null

Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. MW: 145.5 KD.

Glembatumumab (Anti-GPNMB)

Quality Control

Batch: A247501 Purity: 99% Protein concentration: 7.4mg/ml Endotoxin Level: ＜1EU/mg
99

Mechanism of Action

Description
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. MW: 145.5 KD.

Product Details

CAS No. 1020264-78-1
Molecular Weight 145.5 kDa
Isotype Human IgG2SA
Source CHO
Purification AKTA
Sterility 0.2 μM filtered
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02363283 COMPLETED Drug: Glembatumumab Vedotin Recurrent Uveal Melanoma; Stage IV Uveal Melanoma AJCC v7 National Cancer Institute (NCI) 2015-09-16 PHASE2
NCT02302339 TERMINATED Drug: glembatumumab vedotin|Drug: glembatumumab vedotin and Melanoma Celldex Therapeutics 2014-11 PHASE2
NCT02713828 TERMINATED Drug: Phase I: Glembatumumab Vedotin|Drug: Phase II: Glembat Squamous Cell Carcinoma of the Lung PrECOG, LLC. 2016-04-10 PHASE1; PHASE2
NCT03473691 WITHDRAWN Drug: Glembatumumab Vedotin Triple Negative Breast Cancer University of Virginia 2018-05-01 EARLY_PHASE1
NCT03326258 WITHDRAWN Drug: Glembatumumab Vedotin Advanced Malignant Solid Neoplasm; Estrogen Receptor Negative; GPNMB Positive; HER2/Neu Negative; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Progesterone Receptor Negative; Stage III Breast Cancer AJCC v7; Stage III Cutaneous Melanoma AJCC v7; Stage III Uveal Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Breast Cancer AJCC v6 and v7; Stage IV Cutaneous Melanoma AJCC v6 and v7; Stage IV Uveal Melanoma AJCC v7; Triple-Negative Breast Carcinoma; Unresectable Solid Neoplasm National Cancer Institute (NCI) 2018-04-20 PHASE1; PHASE2
NCT02487979 COMPLETED Drug: Glembatumumab Vedotin Recurrent Osteosarcoma National Cancer Institute (NCI) 2016-02-16 PHASE2

(data from https://clinicaltrials.gov, updated on 2020-08-21)

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